ArticleArchives of gerontology and geriatrics plus2024
Cognitive Intra-Individual Variability as an Outcome or Moderator of Speed of Processing Training in Aging Adults with HIV-Associated Neurocognitive Disorder: A Secondary Data Analysis of a 2-Year Longitudinal Randomized Clinical Trial.
Article in Archives of gerontology and geriatrics plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Exploring the potential of cognitive intra-individual variability in HIV care and research in adults with HIV: a concept analysis.Applied neuropsychology. Adult · 2026Review
- Altered angular gyrus activation during the digit symbol substitution test in people living with HIV: beyond information processing speed deficits.Scientific reports · 2025Article
- Cognitive function, mood and sleep changes in response to a Tai Chi/Qigong intervention among older breast cancer survivors: an exploratory analysis.Frontiers in cognition · 2024Article
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Authors and funding
11 authors.
Funding
Abstract
Objective: Cognitive intra-individual variability (IIV), dispersion of cognitive performance across cognitive domains, indicates diminished cognitive control resulting from brain pathology or aging. For people with HIV-Associated Neurocognitive Disorder (HAND), cognitive IIV may interfere with and/or be improved by cognitive training. In this current secondary data analysis, we explored whether cognitive IIV functions as an outcome or moderator variable in speed of processing (SOP) training in middle-aged and older people living with HIV (PLWH). Method: In this randomized clinical trial, 216 PLWH with HAND or borderline HAND were randomized to either: 1) 10 hours of SOP training; 2) 20 hours of SOP training, or 3) 10 hours of Internet Navigation Control Training. Participants completed a seven-domain cognitive battery at baseline, posttest after training, and years 1 and 2 follow up; from this, the coefficient of variation ( Results: Using linear mixed-effect models, no strong pattern of SOP training effects were detected on cognitive IIV. However, a three-way interaction tests between time, group, and baseline cognitive IIV Conclusions: Although SOP training did not improve cognitive IIV, cognitive IIV may be a modifier of SOP training. Implications for future research and other types of training are provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.