ReviewRSC advances2025
Exploring 4D printing of smart materials for regenerative medicine applications.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Critical Systematic Review of 3D Bioprinting in Biomedicine.International journal of molecular sciences · 2025Pooled it
- "Biodegradable caterpillar inspired soft robotic systems for targeted therapeutic delivery with intelligentRSC advances · 2026Review
- Functional Materials for Additive Manufacturing: Materials Design, Processing, and Emerging Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- Review of Progress of AI in Biomimetics: From Biological Patterns to Closed-Loop Discovery.Biomimetics (Basel, Switzerland) · 2026Review
- Bioprinting Organs-Science or Fiction?-A Review From Students to Students.Advanced healthcare materials · 2026Review
- Three-Dimensional Printing of the Epineurium for Peripheral Nerve Repair: A Comprehensive Review of Novel Scaffolds for Nerve Conduits.Biomimetics (Basel, Switzerland) · 2026Review
- Advanced additive manufacturing in orthopedics: a comprehensive review of biomaterials, structural design, biological functions and clinical technology applications.RSC advances · 2026Review
- 4D Printing in Regenerative Medicine: Bio-Inspired Applications for Dynamic Tissue Repair.Journal of functional biomaterials · 2026Review
- Advancing transdermal drug delivery through 4D bioprinting and dynamic skin modelling.Frontiers in drug delivery · 2026Review
- Self-Healing Polymer-Based Coatings: Mechanisms and Applications Across Protective and Biofunctional Interfaces.Polymers · 2025Review
- In Vitro Skin Models as Non-Animal Methods for Dermal Drug Development and Safety Assessment.Pharmaceutics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of biomaterials has evolved rapidly with the introduction of time as a transformative factor, giving rise to four-dimensional (4D) materials that can dynamically change their structure or function in response to external stimuli. This review presents a comprehensive comparison between traditional three-dimensional (3D) and emerging 4D biomaterials, highlighting the key distinctions in design, adaptability, and functionality. We explore the development of smart biomaterials at the core of 4D systems, including stimuli-responsive polymers, shape-memory materials, and programmable hydrogels. The ability of these materials to undergo controlled transformations under physiological or engineered stimuli offers promising avenues in tissue engineering, drug delivery, regenerative medicine, and soft robotics. By integrating responsiveness and temporal control, 4D biomaterials represent a paradigm shift in biomedical engineering, with the potential to revolutionize patient-specific therapies and next-generation implants. Future challenges and opportunities for clinical translation are also discussed.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.