Evidence map›Paper›PMID 40918343›Full record

ArticleACS omega2025

Design, Synthesis, and Molecular Docking Studies of Novel Pyrazoline-Thiazoles as Cholinesterase Dual-Target Inhibitors for the Treatment of Alzheimer's Disease.

Betül Kaya, Ulviye Acar Çevik, Bilge Çiftçi, Adem Necip, Mesut Işik, Ebru Nur Ay, Süleyman Yur, Yusuf Özkay, Şükrü Beydemir, Zafer Asım Kaplancıklı

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Betül KayaVocational School of Health Services, Pharmacy Services, Bilecik Şeyh Edebali University, 11230 Bilecik, Turkey.ORCID https://orcid.org/0000-0002-1713-9485
Ulviye Acar ÇevikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.ORCID https://orcid.org/0000-0003-1879-1034
Bilge ÇiftçiVocational School of Health Services, Bilecik Şeyh Edebali University, 11230 Bilecik, Turkey.
Adem NecipVocational School of Health Services, Pharmacy Services, Harran University, 63300 Şanlıurfa, Turkey.
Mesut IşikDepartment of Bioengineering, Faculty of Engineering, Bilecik Şeyh Edebali University, 11230 Bilecik, Turkey.ORCID https://orcid.org/0000-0002-4677-8104
Ebru Nur AyDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, İstinye University, 34396 İstanbul, Turkey.
Süleyman YurMedicinal Plant, Drug and Scientific Research and Application Center (AUBIBAM), Anadolu University, 26470 Eskişehir, Turkey.
Yusuf ÖzkayDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.ORCID https://orcid.org/0000-0001-5948-1855
Şükrü BeydemirDepartment of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.ORCID https://orcid.org/0000-0003-3667-6902
Zafer Asım KaplancıklıDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.ORCID https://orcid.org/0000-0003-2252-0923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ten novel pyrazoline-thiazole derivatives were synthesized and assessed for their potential as acetylcholinesterase and butyrylcholinesterase inhibitors. The structure of the target compounds was characterized by

Identifiers

PMID40918343
PMCPMC12409578

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.