Evidence map›Paper›PMID 40918662›Full record

ArticleFrontiers in pediatrics2025

Clinical characteristics and factors associated with severe COVID-19 among hospitalized pediatric patients: a retrospective cohort study in the Chaoshan region of China.

Xianyao Wang, Ruiling Ma, Wenshan Zhong, Haipeng Lin, Hachao Zhou, Zhiwei Xiao, Shaofen Lin, Yutao Guo, Xufeng Zheng, Mingxiang Lin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xianyao Wang *Department of Pediatrics, Shantou Central Hospital, Shantou, Guangdong, China.
Ruiling Ma *Department of Pediatrics, Shantou Central Hospital, Shantou, Guangdong, China.
Wenshan ZhongDepartment of Pediatrics, Shantou Central Hospital, Shantou, Guangdong, China.
Haipeng LinDepartment of Pediatrics, Shantou Central Hospital, Shantou, Guangdong, China.
Hachao ZhouDepartment of Pediatrics, Shantou Central Hospital, Shantou, Guangdong, China.
Zhiwei XiaoDepartment of Pediatrics, Shantou Central Hospital, Shantou, Guangdong, China.
Shaofen LinDepartment of Pediatrics, Shantou Central Hospital, Shantou, Guangdong, China.
Yutao GuoDepartment of Pediatrics, Shantou Central Hospital, Shantou, Guangdong, China.
Xufeng ZhengDepartment of Radiology, Shantou Central Hospital, Shantou, Guangdong, China.
Mingxiang LinDepartment of Pediatrics, Shantou Central Hospital, Shantou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Since 2019, COVID-19 has substantially impacted global public health. Although pediatric cases generally manifest with mild symptoms, severe and even fatal outcomes have occurred. Despite the decreased viral transmissibility and pathogenicity observed in the post-pandemic era, identifying early clinical indicators for severe pediatric COVID-19 remains crucial. Method: A retrospective cohort study analyzed 287 hospitalized pediatric COVID-19 patients admitted from December 2022 to August 2023. Clinical and laboratory data were compared between severe/critical and mild/moderate groups using univariable and multivariable analyses. Results: Among hospitalized patients, 82.2% were under 3 years, and severe or critical illness occurred in 32.8%. Fatigue (OR = 2.505, 95% CI: 1.359-4.615, Conclusion: Pediatric COVID-19 hospitalizations predominantly involved children under 3 years of age. Fatigue was independently associated with severe or critical illness, potentially indicating early neurological involvement. Hoarseness was frequently observed in severe cases. Based on our cohort, particular attention may be warranted for children aged 1-1.5 years presenting with neurological symptoms, as all fatal cases (

Indexed as

acute necrotizing encephalitis (ANE)COVID-19hospitalized childrenneurological involvementSARS-CoV-2severe disease

Identifiers

PMID40918662
PMCPMC12408673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.