Evidence mapPaperPMID 40918693Full record

ArticleNEJM AI2025

Artificial Intelligence and Network Medicine: Path to Precision Medicine.

Lucia Altucci, Lina Badimon, Jean-Luc Balligand, Jan Baumbach, Alberico L Catapano, Feixong Cheng, Dawn DeMeo, Rajat Gupta, Marcus Hacker, Yang-Yu Liu and 7 more

Abstract read
In one paragraph

Article in NEJM AI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lucia AltucciDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.ORCID 0000-0002-7312-5387
Lina BadimonCardiovascular Program, Catalan Institute of Cardio-Vascular Science (ICCC) and Spanish Research Consortium on Cardiovascular Diseases, Research Institute Hospital de la Santa Creu i Sant Pau, Barcelona.ORCID 0000-0002-9162-2459
Jean-Luc BalligandInstitute of Experimental and Clinical Research, Catholic University of Louvain, Brussels.ORCID 0000-0002-0522-4156
Jan BaumbachInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0002-0282-0462
Alberico L CatapanoScientific Institute of Recovery and Care MultiMedica and University of Milan, Milan.ORCID 0000-0002-7593-2094
Feixong ChengCleveland Clinic Genome Center, Cleveland Clinic Research, Cleveland Clinic, Cleveland.ORCID 0000-0002-1736-2847
Dawn DeMeoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston.ORCID 0000-0001-9653-0636
Rajat GuptaDivisions of Cardiovascular Medicine and Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston.ORCID 0000-0001-9865-4106
Marcus HackerDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University, Vienna.ORCID 0000-0002-4222-4083
Yang-Yu LiuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston.ORCID 0000-0003-2728-4907
Joseph LoscalzoDivision of Cardiovascular Medicine, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston.ORCID 0000-0002-1153-8047
Sabrina ManiscalcoUniversity of Helsinki, Helsinki.ORCID 0000-0001-8559-0828
Jörg MencheLudwig Boltzmann Institute for Network Medicine, University of Vienna, Vienna.ORCID 0000-0002-1583-6404
Giulia MenichettiDepartment of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland.ORCID 0000-0001-5201-6774
Paolo PariniCardio Metabolic Unit, Department of Medicine and Department of Laboratory Medicine, Karolinska Institute, and Inflammation and Ageing Theme, Karolinska University Hospital, Stockholm.ORCID 0000-0002-6541-8542
Harald H H W SchmidtDepartment of Pharmacology and Personalised Medicine, Faculty of Health, Medicine and Life Science, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands.ORCID 0000-0003-0419-5549
Marinka ZitnikDepartment of Biomedical Informatics, Harvard Medical School, Boston.ORCID 0000-0001-8530-7228

Funding

Methods for Unraveling the Impact of Dietary Xenobiotics on COPD Exacerbations with Multi-Dimensional NetworksK25HL173665 · BRIGHAM AND WOMEN'S HOSPITAL · 2025 to 2025
$161k
NHGRI NIH HHS U01 HG007690NHLBI NIH HHS K25 HL173665NINDS NIH HHS U01 NS134357
6 · The paper itself

Abstract

Over the past two decades, network medicine (NM) has evolved to help define disease mechanisms, identify drug targets, and guide increasingly precise therapies. In recent years, the integration of NM with artificial intelligence (AI), particularly deep learning techniques, has evolved with increasing applications. AI techniques help elucidate complex disease mechanisms and define precise therapies. The depth of useful, mechanistic information implicit in molecular interaction networks and prior deep learning successes provide a rational basis for combining NM and AI in the analyses of large multiomic datasets to enhance the speed, predictive precision, and biological insights of the computational process. In this review, we provide a summary of concepts related to the combined use of AI and NM as a path to precision medicine, illustrating the success of this joint approach to biomedical complexity and its ongoing challenges.

Identifiers

PMID40918693
PMCPMC12410635

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.