Evidence map›Paper›PMID 40918750›Full record

ArticleInternational journal of cardiology. Heart & vasculature2025

Cardiac biomarkers for the quantification of myocardial damage after cardiac surgery - The RORSCHACH trial.

Tulio Caldonazo, Marcus Winter, Michael Kiehntopf, René Aschenbach, Stephanie Gräger, Sebastian Reinartz, André Scherag, Ulrike Schumacher, Hristo Kirov, Ulf Teichgräber and 2 more

Registry-linked trialAbstract read
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In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06066970 (Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06066970 recruitingnot on this map

Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery

TypeobservationalSponsorJena University HospitalRan2023 to 2025Enrolled100ConditionsCardiac Valve Disease
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tulio CaldonazoDepartment of Cardiothoracic Surgery, Friedrich-Schiller-University Jena, University Hospital Jena, Germany.
Marcus WinterCenter for Clinical Studies, University Hospital Jena, Germany.
Michael KiehntopfDepartment of Clinical Chemistry and Laboratory Diagnostics, University Hospital Jena, Germany.
René AschenbachDepartment of Diagnostic and Interventional Radiology, University Hospital Jena, Germany.
Stephanie GrägerDepartment of Diagnostic and Interventional Radiology, University Hospital Jena, Germany.
Sebastian ReinartzDepartment of Diagnostic and Interventional Radiology, University Hospital Jena, Germany.
André ScheragInstitute of Medical Statistics, Computer and Data Sciences, University Hospital Jena, Germany.
Ulrike SchumacherCenter for Clinical Studies, University Hospital Jena, Germany.
Hristo KirovDepartment of Cardiothoracic Surgery, Friedrich-Schiller-University Jena, University Hospital Jena, Germany.
Ulf TeichgräberDepartment of Diagnostic and Interventional Radiology, University Hospital Jena, Germany.
Torsten DoenstDepartment of Cardiothoracic Surgery, Friedrich-Schiller-University Jena, University Hospital Jena, Germany.
RORSCHACH Investigators and GermaN HeaRTS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiac biomarkers are important components for diagnosing perioperative myocardial infarction (MI). Efforts to detect MI by biomarker-release only faced heavy criticism, because cardiac biomarker-release has also been observed in situations that are not always related to cell death (e.g., renal insufficiency, neurological diseases, and even after endurance exercise). This study correlates release patterns of all three classically used cardiac injury biomarkers (CK/CK-MB, Troponin T and I) with myocardial damage visualized by late gadolinium enhanced cardiac magnetic resonance imaging (LGE-cMRI) and also compares biomarkers among each other. Methods and analysis: The RORSCHACH study is a prospective, multicenter, single-armed, non-blinded, non-controlled study evaluating cardiac biomarker release during elective aortic or mitral valve surgery and their correlation to perioperative myocardial damage as detected by MRI. Enrolled patients undergo routine monitoring including echocardiography, electrocardiography, cardiac biomarker analyses, and clinical symptom assessment preoperatively (within 24 h prior to surgery) and postoperative at predefined timepoints. LGE-cMRI is performed preoperatively and at least 5 days after surgery to clinically quantify any new myocardial damage. In total, 100 patients will be enrolled, whereby a drop-out rate of 15 % subsequently results in 85 patients necessary for final analysis. The primary endpoint is the correlation of the peak value of the respective biomarker with the amount of perioperatively induced myocardial damage quantified by LGE-cMRI. Discussion: The RORSCHACH trial will deliver the first comparative and quantitative information on the predictive value of the three classic cardiac injury markers used for the detection of new perioperative irreversible injury/MI in cardiac surgery. Study registration: Clinicaltrials.gov. NCT06066970. Registered on September 28th 2023.

Indexed as

Cardiac biomarkerMyocardial infarctionTroponin

Identifiers

PMID40918750
PMCPMC12409798

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.