ReviewCureus2025
Diagnostic Utility of Diffusion Tensor Imaging and Functional MRI in Early Neurodegeneration: A Systematic Review of Structural and Functional Brain Biomarkers.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review explores the application of advanced neuroimaging techniques, diffusion tensor imaging (DTI) and functional MRI (fMRI), in identifying early neural alterations in patients with cognitive impairment and neurodegenerative disorders. By synthesizing data from nine recent clinical studies, the review highlights the integration of structural and functional imaging in detecting subtle brain connectivity changes associated with conditions such as mild cognitive impairment (MCI), Parkinson's disease, Alzheimer's disease, and subjective cognitive decline (SCD). The findings suggest that specific imaging parameters, including fractional anisotropy and task-based functional deactivation, correlate strongly with cognitive outcomes and therapeutic responses. Overall, this work underscores the potential of DTI and fMRI as valuable, non-invasive biomarkers for early detection and monitoring of cognitive decline, offering a foundation for improved diagnostic accuracy and timely interventions in clinical settings.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.