ArticleCureus2025
Cerebral Tuberculoma in a Patient With Pre-extensively Drug-Resistant Tuberculosis and AIDS: Diagnostic and Management Challenges.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Extrapulmonary tuberculosis (TB), particularly when it involves the central nervous system (CNS), remains a significant clinical challenge. Cerebral tuberculoma, though rare, can present with complex symptoms that overlap with other neurological conditions, making timely diagnosis difficult. The condition demands a multidisciplinary approach for accurate diagnosis and effective management, especially in patients with multiple comorbidities. This report describes a complex case of pre-extensively drug-resistant TB affecting both the lungs and CNS in a 54-year-old immunocompromised male with AIDS, chronic hepatitis B and C, COVID-19, and reactivated varicella. The patient presented with systemic symptoms and new-onset neurological deficits, including seizures and right-sided paresis. Brain MRI revealed a cerebral tuberculoma with surrounding edema. Sputum testing confirmed
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