Evidence map›Paper›PMID 40918898›Full record

ArticleCureus2025

Beyond the First Year of Intravitreal Faricimab for Diabetic Macular Oedema: A Single-Centre Experience.

Theodore Tsilegeridis-Legeris, Nihal Kenawy

Abstract read
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Theodore Tsilegeridis-LegerisOphthalmology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, GBR.
Nihal KenawyOphthalmology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective To determine real-world clinical outcomes (including vision, anatomy and durability) of intravitreal faricimab (IVF) in year two (up to mean follow-up of 75 ± 15 weeks, range: 52-103 weeks) of treating diabetic macular oedema (DMO). Secondary objectives included assessing changes in diabetic retinopathy (DR) severity, the incidence of epiretinal proliferation (ERP)/epiretinal membrane (ERM), and safety. Methodology This is a single-centre retrospective observational study. Eligible eyes with ≥52 weeks follow-up, October 2022 to November 2024, were identified and categorised into naïve (no prior anti-vascular endothelial growth factor (anti-VEGF) agents) and switch (≥1 prior anti-VEGF). Descriptive statistics at week 52 (W52) and end of follow-up (EOFU) summarised mean BCVA and CFT change, mean IVF injections and frequency, DR severity change, epiretinal proliferation (ERP)/membrane (ERM) incidence, and safety. Results In total, 158 eyes (66 naïve, 92 switch) of 118 patients were identified, mean follow of 75 weeks. Mean W52 BCVA change was +3.6 (

Indexed as

anti-vegf treatmentdiabetic macular edema (dme)diabetic macular oedemafaricimabfaricimab intravitreal injenctionintravitreal anti vegfintravitreal injectionsreal-worldreal-world data

Identifiers

PMID40918898
PMCPMC12413623

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.