ArticleFrontiers in oncology2025
Burden and trends of ovarian and uterine cancer due to high body mass index from 1990 to 2021: an age-period-cohort study based on the GBD 2021, and projections through 2036.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The mediating pathways of frailty on healthcare costs and length of stay in older patients with colorectal cancer: a multicenter retrospective study.Frontiers in medicine · 2026Article
- Global Burden of Ovarian Cancer and Causal Risk Factors from 1990 to 2021: An Integrated GBD and Mendelian Randomization Analysis.International journal of women's health · 2026Article
- Identification of LILRB4 as a regulator of M2c macrophages and a potential immunotherapeutic target in ovarian cancer.Frontiers in immunology · 2026Article
- Development and evaluation of a machine learning-based risk prediction model for enteral feeding intolerance in sepsis patients.Frontiers in nutrition · 2026Article
- Burden and Risk Factor Patterns of Reproductive System Tumors and Non-Tumor Diseases Among Asian Women, 1990-2021: Evidence from the GBD Study.International journal of women's health · 2026Article
- Global, Regional, and National Burden of Breast Cancer Attributable to Low Physical Activity in Women of Reproductive Age: Historical Trends from 1990 to 2021 and Projections to 2035.Archives of Iranian medicine · 2025Article
- SLC40A1-mediated positive feedback loop with M1 macrophages suppresses epithelial ovarian cancer progression.Frontiers in immunology · 2025Article
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Abstract
Background: Ovarian cancer (OC) and uterine cancer (UC) are significant public health concerns among women of reproductive age. High body mass index (BMI) contributes to the increasing burden of these cancers globally, but comprehensive epidemiological assessments remain limited. Methods: Data were obtained from the Global Burden of Disease (GBD) Study 2021 (1990-2021). Deaths, disability-adjusted life-years (DALYs), and corresponding age-standardized rates (ASRs) were calculated to assess disease burden. Burden by age was analyzed in five-year intervals. Differences across Sociodemographic Index (SDI) quintiles were compared. Temporal trends from 1990 to 2021 were assessed using estimated annual percentage change and absolute number changes. Future ASRs were projected to 2036 using a Bayesian age-period-cohort model. Results: In 2021, an estimated 2,022 (95% uncertainty interval [UI], 473-3,611) deaths and 99,915 (95% UI, 22,387-178,579) DALYs from OC attributable to high BMI occurred among women of reproductive age, with Eastern Europe exhibiting the highest age-standardized mortality rate and DALYs among 21 GBD regions. For UC, there were 2,202 (95% UI, 1,545-2,910) deaths and 114,117 (95% UI, 80,122-150,221) DALYs, with the Caribbean among the regions with the highest burden. From 1990 to 2021, ASRs for mortality and DALYs for both OC and UC attributable to high BMI significantly increased and are projected to continue rising over the next 15 years. The burden increased with age, peaking at 45-49 years. Regionally, burden rose in low- and middle-SDI areas, while high-SDI regions showed initial increases followed by declines. Conclusions: The rising mortality and DALYs of OC and UC attributable to high BMI, especially in low- and middle-SDI regions and high-burden areas such as Eastern Europe and the Caribbean, highlight an urgent need for targeted prevention and weight management interventions among women of reproductive age.
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