Association between mental work and biological aging: the mediating role of visceral adiposity index.

Kangnan Zhang, Rongdi Xu, Yuhe Liu, Wenqian Wu, Yong Zhou

Abstract read

In one paragraph

Article in Innovation in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kangnan ZhangClinical Research Institute, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China.

Rongdi XuClinical Research Institute, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China.

Yuhe LiuClinical Research Institute, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China.

Wenqian WuClinical Research Institute, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China.

Yong ZhouClinical Research Institute, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: This study aimed to investigate the relationship between mental work, work intensity, and accelerated biological aging, focusing on the mediating role of the Visceral Adiposity Index (VAI). Research Design and Methods: In this cross-sectional study, data were collected from the Kailuan physical activity cohorts in the Asia-Pacific region. Biological aging was assessed using PhenoAge and Klemera-Doubal method age (KDMAge) acceleration. Multivariable linear regression models examined the link between mental work and biological aging, while mediation analysis assessed the role of VAI. Results: Among 3,933 participants (mean age 56.4 years; 55.6% male), mental workers showed greater biological age (BA) acceleration: KDMAge acceleration increased by 1.52 years ( Discussion and Implications: Mental work is associated with accelerated biological aging. These results highlight the importance of interventions targeting work intensity and metabolic health to reduce age-related disease burdens.

Indexed as

job typeKDMAgePhenoAge

Identifiers

PMID40919507

DOI10.1093/geroni/igaf077

PMCPMC12409274

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.