ReviewInternational journal of surgery (London, England)2026
Cancer-associated fibroblasts as a potential therapeutic target for thyroid cancers.
Review in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Therapeutic Potential of Tyrosine Kinase Inhibitors in Advanced Thyroid Cancer.Current oncology reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid cancer, a prevalent endocrine malignancy, is influenced by its tumor microenvironment (TME), with cancer-associated fibroblasts (CAFs) playing a pivotal role in disease progression. Molecularly, CAFs orchestrate a pro-tumorigenic niche via cytokine secretion and extracellular matrix (ECM) stiffening, underscoring their targetability. Therapeutic strategies, including small molecule inhibitor-based therapies, immune-based therapies, nanoparticle-based approaches, and combination regimens, have been evaluated for their efficacy in disrupting CAF functionality. CAFs from resident fibroblasts or recruited precursors can promote the progression of thyroid cancer through ECM remodeling, angiogenesis, and epithelial-mesenchymal transition (EMT) induction while facilitating immune evasion. These processes can enhance tumor invasiveness, metastasis, and resistance to conventional therapies. Preclinical studies using thyroid cancer models have demonstrated promising outcomes, such as reduced tumor burden and enhanced drug sensitivity upon CAF inhibition. Emerging clinical trials have tested CAF-directed agents in patient cohorts and validated these findings. However, many challenges persist, including the identification of reliable CAF-specific biomarkers, optimization of treatment timing, and integration of the biomarkers into personalized medicine frameworks. This review explores the therapeutic potential of CAFs for thyroid cancers, emphasizing their origin, activation, and multifaceted contributions to tumor growth. This review synthesizes current evidence, highlighting CAFs as a novel therapeutic frontier for thyroid cancers. Future research should focus on refined biomarker discovery and strategic therapeutic sequencing to maximize clinical benefits, providing a roadmap for translating CAF-targeted approaches into effective treatments for thyroid cancers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.