Evidence map›Paper›PMID 40920168›Full record

ArticleJournal of medicinal chemistry2025

Sustainable Antiparasitic Agents from an Agro-Industrial Waste: Mitochondria-Targeting Cashew Nutshell Liquid-Derived Phosphonium and Ammonium Salts.

Bianca Martinengo, Cecilia Baldassarri, Kayhan Ilbeigi, Hamed E Alkhalaf, Aditya Sarode, Ehab Kotb Elmahallawy, Ba Reum Kwon, Amos Sarpong Agyei, Aigerim Abdimanova, Ludmila Ferreira de Almeida Fiuza and 15 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Advancing the Understanding of the Mo-CBPProbiotics and antimicrobial proteins · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Bianca MartinengoDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum─University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.ORCID 0000-0002-4239-8120
Cecilia BaldassarriMedicinal Chemistry Unit, School of Pharmacy, Chemistry Interdisciplinary Project (ChIP), University of Camerino, Via Madonna delle Carceri, Camerino 62032, Italy.ORCID 0000-0002-9708-5789
Kayhan IlbeigiLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0003-2955-5096
Hamed E AlkhalafSchool of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G43 2DX, U.K.ORCID 0009-0005-2296-1309
Aditya SarodeSchool of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G43 2DX, U.K.ORCID 0000-0001-7521-1257
Ehab Kotb ElmahallawySchool of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G43 2DX, U.K.ORCID 0000-0003-4484-3678
Ba Reum KwonDepartment of Environmental Science, Baylor University, Waco, Texas 76798-7266, United States.
Amos Sarpong AgyeiDepartment of Environmental Science, Baylor University, Waco, Texas 76798-7266, United States.ORCID 0000-0002-4446-9500
Aigerim AbdimanovaDepartment of Environmental Science, Baylor University, Waco, Texas 76798-7266, United States.
Ludmila Ferreira de Almeida FiuzaLaboratório de Biologia Celular do Instituto Oswaldo Cruz, Fiocruz. Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040360, Brazil.
Raquel AzevedoLaboratório de Biologia Celular do Instituto Oswaldo Cruz, Fiocruz. Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040360, Brazil.
Ketlym da ConceiçãoLaboratório de Biologia Celular do Instituto Oswaldo Cruz, Fiocruz. Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040360, Brazil.
Marcos Meuser BatistaLaboratório de Biologia Celular do Instituto Oswaldo Cruz, Fiocruz. Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040360, Brazil.
Ellyêssa Nascimento BorgesFaculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Goiás 74605-220, Brazil.
Kleber Santiago Freitas E SilvaFaculdade de Farmácia, Universidade Federal de Goiás, Goiânia, Goiás 74605-220, Brazil.ORCID 0000-0001-5350-7313
Éder Jéferson Souza CardosoInstituto de Física, Universidade Federal de Goiás, Goiânia, Goiás 74690-900, Brazil.
Natália Cipriano MonteiroLaboratório de Desenvolvimento de Inovaçõ Terapêutica, Centro de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília 70910-900, Brazil.ORCID 0009-0005-3625-8446
Lais Flavia Nunes LemesLaboratório de Desenvolvimento de Inovaçõ Terapêutica, Centro de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília 70910-900, Brazil.ORCID 0000-0002-2904-5291
Luiz Antonio Soares RomeiroLaboratório de Desenvolvimento de Inovaçõ Terapêutica, Centro de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília 70910-900, Brazil.ORCID 0000-0001-5679-0820
Antonio AlonsoInstituto de Física, Universidade Federal de Goiás, Goiânia, Goiás 74690-900, Brazil.ORCID 0000-0003-4768-6372
Maria de Nazaré Correia SoeiroLaboratório de Biologia Celular do Instituto Oswaldo Cruz, Fiocruz. Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040360, Brazil.
Guy CaljonLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Infla-Med Centre of Excellence, University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0002-4870-3202
Bryan W BrooksDepartment of Environmental Science, Baylor University, Waco, Texas 76798-7266, United States.ORCID 0000-0002-6277-9852
Harry P De KoningSchool of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G43 2DX, U.K.ORCID 0000-0002-9963-1827
Maria Laura BolognesiDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum─University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.ORCID 0000-0002-1289-5361

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innovative, sustainable therapies are urgently needed for neglected vector-borne parasitic diseases. In this study, we leveraged cashew nutshell liquid (CNSL), an agro-industrial byproduct, to develop biobased phosphonium and ammonium salts (

Indexed as

AnacardiumAntiparasitic AgentsMitochondriaOrganophosphorus CompoundsQuaternary Ammonium CompoundsAnimalsDaphniaLeishmaniaParasitic Sensitivity TestsStructure-Activity RelationshipTrypanocidal AgentsTrypanosomaTrypanosoma brucei bruceiAntiparasitic AgentsOrganophosphorus CompoundsQuaternary Ammonium CompoundsTrypanocidal Agents

Identifiers

PMID40920168
PMCPMC12481484

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.