Evidence map›Paper›PMID 40920279›Full record

ArticleMolecular biology reports2025

Demethoxycurcumin induces apoptosis and reduces cell migration by affecting AKT/mTOR-dependent autophagy in human glioma U87MG and T98G cell lines.

Bhavna Sharma, Neetika Lal, Kavita Dixit, Niharika, Laishram R Singh, Pratibha Mehta Luthra

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Bhavna SharmaDr. B. R. Ambedkar Centre for Biomedical Research North Campus , University of Delhi , 110007, Delhi, India.
Neetika LalDr. B. R. Ambedkar Centre for Biomedical Research North Campus , University of Delhi , 110007, Delhi, India.
Kavita DixitDr. B. R. Ambedkar Centre for Biomedical Research North Campus , University of Delhi , 110007, Delhi, India.
NiharikaDr. B. R. Ambedkar Centre for Biomedical Research North Campus , University of Delhi , 110007, Delhi, India.
Laishram R SinghDr. B. R. Ambedkar Centre for Biomedical Research North Campus , University of Delhi , 110007, Delhi, India.
Pratibha Mehta LuthraDr. B. R. Ambedkar Centre for Biomedical Research North Campus , University of Delhi , 110007, Delhi, India. pmlsci2020@gmail.com.

Funding

DBT-BIC-2020 BT/PR401543/BTIS/137/8/2021Institution of Eminence, University of Delhi, India IoE/FRP/LS/2020/27
6 · The paper itself

Abstract

backgroundStandard treatment for glioblastoma includes chemotherapy, alkylating agents such as temozolomide (TMZ); however, MGMT resistance leads to recurrence. Demethoxycurcumin (DMC) has been reported to inhibit cancer cell growth, induce apoptosis, and prevent metastasis in different cancer models. We investigated the DMC-induced apoptosis and autophagy via inhibition of the AKT/mTOR pathway in human glioma U87MG and T98G cell lines. MATERIALS AND

methodsU87MG and T98G cell lines were exposed to various concentrations of DMC to cell viability, ROS production and apoptosis. Levels of apoptosis and autophagy-related proteins such as Cyt c, Akt, mTOR, Beclin-1 and LC3I/II were measured by western blot. Autophagic protein LC3I/II was confirmed by immunofluorescence staining. Cell migration after 24 h using a wound-healing assay.

resultsDMC induced reactive oxygen species (ROS) generation, leading to apoptosis and inhibited the survival proteins to trigger autophagy and effectively suppressed cell migration in both U87MG and T98G cell lines. Apoptosis and autophagy were more prominent in U87MG cells, whilereduction in cell migration was in T98G cells.

conclusionDMC induces cell death via ROS generation leads to apoptosis and autophagy through the Akt/mTOR pathway in U87MG and T98G cell lines. This study offers novel insights into the therapeutic potential of DMC for glioblastoma treatment.

Indexed as

ApoptosisCurcuminDiarylheptanoidsGliomaAutophagyCell Line, TumorCell MovementCell ProliferationCell SurvivalHumansProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSignal TransductionTOR Serine-Threonine KinasesCurcumindemethoxycurcuminDiarylheptanoidsMTOR protein, humanProto-Oncogene Proteins c-aktReactive Oxygen SpeciesTOR Serine-Threonine KinasesAKT/mTORApoptosisAutophagyDMCGlioblastomaGlioma cell lines

Identifiers

PMID40920279

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.