Evidence map›Paper›PMID 40920489›Full record

ArticleMicrobiology spectrum2025

Zika virus impairs autophagic flux in trabecular meshwork, and inhibition of autophagy restricts ocular viral transmission and associated pathology.

Faraz Ahmad, Prince Kumar, Pallav Singh, Trupti Joshi, Pawan Kumar Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Faraz Ahmad *Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, Missouri, USA.ORCID 0000-0002-5401-5027
Prince Kumar *Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, Missouri, USA.ORCID 0000-0002-0296-3332
Pallav SinghMU Institute of Data Science and Informatics, University of Missouri, Columbia, Missouri, USA.
Trupti JoshiMU Institute of Data Science and Informatics, University of Missouri, Columbia, Missouri, USA.ORCID 0000-0001-8944-4924
Pawan Kumar SinghDepartment of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, Missouri, USA.ORCID 0000-0001-5517-1120

Funding

Role of Zika virus (ZIKV) infection in glaucoma pathobiologyR01EY032495 · NEI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SINGH, PAWAN KUMAR · 2021 to 2025
$2.0M
Missouri Department of Health and Senior Services AOC23380006NEI NIH HHS R01 EY032495NEI NIH HHS R01EY032495University of Missouri School of Medicine Research start-up funds
6 · The paper itself

Abstract

Zika virus (ZIKV) is the lone member of Flavivirus family known to cause congenital glaucoma following IMPORTANCE:

Indexed as

AutophagyTrabecular MeshworkZika VirusZika Virus InfectionAnimalsDisease Models, AnimalFemaleGlaucomaHumansHydroxychloroquineLysosomesMiceMice, Inbred C57BLMice, KnockoutReceptor, Interferon alpha-betaVirus ReplicationHydroxychloroquineReceptor, Interferon alpha-betaautolysosomeautophagosomeautophagyeyeglaucomaHCQretinatrabecular meshworkZika virus

Identifiers

PMID40920489
PMCPMC12502531

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.