ArticleAmerican journal of physiology. Heart and circulatory physiology2025
Oral nitrate-reducing capacity and aerobic fitness are impaired in older individuals with heart failure with reduced ejection fraction.
Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Beetroot Juice Enhances Nitrate Metabolism and Endothelial Function but Not Cardiovascular or Strength Performance in Bodybuilders with a History of Anabolic-Androgenic Steroid Abuse: A Crossover Trial.Antioxidants (Basel, Switzerland) · 2026Article
- Influence of exercise training on nitric oxide pathways and their physiological effects.Redox biology · 2026Review
- Oral microbiota in cardiovascular health and disease.Frontiers in cellular and infection microbiology · 2025Review
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Authors and funding
8 authors.
Funding
Abstract
Nitric oxide (NO) is essential for cardiovascular health and is purported as an ergogenic aid. Endothelial dysfunction and reduced endogenous NO production are hallmarks of heart failure (HF), which may contribute to impaired exercise capacity. Oral inorganic nitrate supplementation offers an exogenous route to increase bioavailable NO via reduction of nitrate by oral commensal bacteria. However, individuals with HF with reduced ejection fraction (HFrEF) display blunted increases in plasma nitrite and inconsistent improvements in exercise tolerance following supplementation. Thus, the purpose of this study was to examine whether bacterial oral nitrate-reducing capacity (ONRC) and markers of exercise capacity are impaired in patients with HFrEF compared with age-matched, healthy controls. Nine individuals with HFrEF [age: 74.89 ± 7.40 yr, peak oxygen consumption (V̇o
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Registered trials
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