ReviewCancer science2025
Canonical and Non-Canonical Functions of Histone H3K4 Methylation Modifiers in Cancer.
Review in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Establishment of a Common Marmoset Lineage Carrying a Frameshift Mutation in SETD1A, a Schizophrenia Risk Gene.Journal of neurochemistry · 2026Article
- The role of histone methylation in fibrosis and its therapeutic potential.Journal of translational medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Histone H3K4 modifications are altered in the regulation of gene expression and in multiple cellular processes during cancer development and progression. Understanding the roles of H3K4-modifying enzymes will provide novel insights into therapeutic tools for cancer treatment. H3K4-modifying enzymes catalyze the addition or removal of covalent modifications with specific substrate preferences. Although these proteins are evolutionarily conserved between yeast and mammals, their protein domains and functions are not identical, and they exhibit signs of evolutionary divergence. Recent studies have indicated that H3K4-modifying enzymes play non-canonical roles via non-histone substrates or non-catalytic functions. Here, we discuss both canonical and non-canonical functions of H3K4-modifying enzymes and their potential benefits for therapeutic applications in cancer therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.