Evidence map›Paper›PMID 40922009›Full record

ArticleBreast cancer research : BCR2025

Polygenic scores in Familial breast cancer cases with and without pathogenic variants and the risk of contralateral breast cancer.

Anders Kvist, Anders Kämpe, Therese Törngren, Bianca Tesi, Panagiotis Baliakas, Åke Borg, Daniel Eriksson

Abstract read
In one paragraph

Article in Breast cancer research : BCR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Polygenic scores as modifiers in Mendelian diseases.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anders KvistDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Anders KämpeDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Therese TörngrenDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Bianca TesiDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Panagiotis BaliakasDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Åke BorgDivision of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Daniel ErikssonDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. daniel.eriksson@igp.uu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolygenic risk scores (PRS) are not yet standard in clinical risk assessments for familial breast cancer in Sweden. This study evaluated the distribution and impact of an established PRS (PRS

findingsWe integrated PRS

conclusionsWomen with familial breast cancer showed elevated PRS

Indexed as

Biomarkers, TumorBreast NeoplasmsGenetic Predisposition to DiseaseMultifactorial InheritanceAdultAgedFemaleGenetic TestingHumansMiddle AgedPenetranceRisk AssessmentRisk FactorsSwedenBiomarkers, Tumor

Identifiers

PMID40922009
PMCPMC12418628

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.