Evidence map›Paper›PMID 40922699›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Real-Time Visualisation of Reaction Kinetics and Dynamics: Single-Molecule Insights into the Iminium-Catalysed Diels-Alder Reaction.

Minsoo Park, Yongdeok Ahn, Juhyeong Cho, Juhee Jang, Wonhee J Lee, Sangwon Seo, Sunggi Lee, Daeha Seo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Minsoo Park *Department of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea.
Yongdeok Ahn *Department of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea.
Juhyeong ChoDepartment of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea.
Juhee JangDepartment of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea.
Wonhee J LeeDepartment of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea.
Sangwon SeoDepartment of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea.
Sunggi LeeDepartment of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea.
Daeha SeoDepartment of Physics and Chemistry, DGIST, Daegu, 42988, Republic of Korea.ORCID https://orcid.org/0000-0002-0454-1168

Funding

National Research Foundation of Korea 2020M3A9D8038014National Research Foundation of Korea RS-2021-NR060139National Research Foundation of Korea RS-2024-00355795National Research Foundation of Korea RS-2024-00454580the DGIST Program of the MSIT 21-HRHR+-02the DGIST Program of the MSIT 21-HRHR-05
6 · The paper itself

Abstract

Investigation of the fundamental microscopic processes occurring in organic reactions is essential for optimising both organocatalysts and synthetic strategies. In this study, single-molecule fluorescence microscopy was employed to study the Diels-Alder reaction catalysed by a first-generation MacMillan catalyst, providing direct insights into its kinetic dynamics. This reaction proceeds via a series of reversible processes under equilibrium conditions (S ⇄ IM

Indexed as

Diels–Alder reactionHidden Markov ModelReal‐timeSecondary amine catalystSingle‐molecule imaging

Identifiers

PMID40922699
PMCPMC12582012

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.