ReviewCureus2025
Crush Syndrome and Systemic Necrosis in Trauma Patients: A Systematic Review of Pathophysiology, Anatomical Impact, and Renal Outcomes.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Risk factors associated with postoperative necrosis after digital replantation: a systematic review and meta-analysis.Frontiers in surgery · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crush syndrome remains a life-threatening complication of traumatic injuries, especially in mass casualty and disaster scenarios. This systematic review evaluates the current clinical and mechanistic understanding of crush-related pathophysiology, anatomical impact, and renal complications, with a focus on therapeutic interventions. Studies were selected using the PICO framework and analyzed under PRISMA guidelines. A total of six studies, including narrative reviews, clinical trials, and a systematic review, were included. Core findings highlighted ischemia-reperfusion injury, rhabdomyolysis, and ferroptosis as key drivers of systemic toxicity, often culminating in acute kidney injury (AKI). Anatomically, prolonged soft tissue compression and necrosis posed serious risks for long-term disability and systemic inflammation. Adjunctive therapies such as hyperbaric oxygen therapy (HBOT) demonstrated potential benefits in wound healing and tissue preservation, though evidence remains limited by study heterogeneity. Overall, this review offers an integrative synthesis of existing knowledge, identifies therapeutic gaps, and emphasizes the need for standardized, evidence-based protocols for managing crush syndrome.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.