ArticleCureus2025
Prognostic Value of Perioperative Serum Creatinine Kinase Levels for Metachronous Colorectal Liver Metastasis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
backgroundAlthough decreased serum creatine kinase (s-CK) levels are observed in some cancers, possibly due to consumption during tumor growth, the relationship between s-CK levels and colorectal liver metastasis remains unclear. This study investigated the prognostic significance of perioperative s-CK levels in patients with metachronous colorectal liver metastasis.
methodsA total of 46 patients who underwent liver resection from 2011 to 2023 were included in this study. The s-CK levels were assessed before liver resection and six months after liver resection. The patients were categorized into low or high s-CK groups, and the lower limit of normal s-CK levels was set as the cutoff value. The prognostic significance for recurrence-free survival (RFS) and overall survival (OS) was analyzed.
resultsThere was no significant difference in RFS or OS between the preoperative low and preoperative high s-CK groups (P = 0.089, P = 0.132, respectively). There was a significant difference in RFS between the postoperative low and postoperative high s-CK groups (P = 0.001). However, there was no significant difference in OS between these groups (P = 0.072). Patients with consistently low s-CK levels before and six months after liver resection showed significantly poorer RFS (P = 0.002) and poorer OS (P = 0.038) compared with patients who had consistently high s-CK levels.
conclusionPerioperative s-CK levels may be useful as predictors of prognosis in patients with metachronous colorectal liver metastasis. Patients with consistently low perioperative s-CK levels may have a high risk for recurrence and mortality.
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