ArticleWorld journal of pediatric surgery2025
Effect of prenatal heparin-binding epidermal growth factor (HB-EGF) administration on necrotizing enterocolitis-induced lung injury in a murine model.
Article in World journal of pediatric surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Necrotizing enterocolitis (NEC) is a gastrointestinal emergency in premature neonates. NEC is mediated by toll-like receptor-4 (TLR-4) and associated with lung injury. Previously, we showed that prenatal heparin-binding epidermal growth factor (HB-EGF) administration decreases the incidence of intestinal injury in a rat model of NEC. We tested the hypothesis that prenatally administered HB-EGF would decrease TLR-4 activation and lung injury in a murine model. Methods: Pregnant mice were given HB-EGF (800 μg/kg/dose) via intraperitoneal injection prior to cesarean section. Pups were exposed to a NEC model and sacrificed on signs of NEC. We collected tissue, performed histological grading of NEC, evaluated alveolar morphometry, and counted TLR-4-expressing cells by immunohistochemistry, unbiased stereology, and quantified TLR-4 protein via ELISA. Results: Mean alveolar area was significantly different between HB-EGF and control groups compared with NEC only (HB-EGF>NEC; Conclusions: Our results suggest that prenatal HB-EGF administration preserves lung morphometry and decreases TLR-4 in a murine model of NEC. Possibly, the administration of HB-EGF prenatally to pregnant mothers at risk of delivering a premature infant susceptible to NEC may prevent lung injury.
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