ArticleEquine veterinary journal2026
The potential value of cytokine, cortisol and vitamin D profiles in foals from birth to weaning for respiratory disease prediction on a farm endemic for Rhodococcus equi pneumonia.
Article in Equine veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
Funding
Abstract
backgroundRhodococcus equi causes pneumonia in young foals, but disease susceptibility and severity vary. Cortisol and vitamin D modulate immune responses and cytokine production during bacterial infection, and altered concentrations are associated with sepsis in neonatal foals. We hypothesised an age and disease effect on circulating steroid hormone concentrations in foals, and that differences in cytokines and steroid hormone concentrations would predict disease severity in pneumonic foals.
objectivesTo investigate circulating concentrations of various cytokines, cortisol and vitamin D as predictors of individual disease severity in R. equi foals. STUDY
designProspective cohort.
methodsBlood samples were collected from 200 initially healthy foals on a pneumonia-endemic breeding farm after birth and at 1, 2, 4, 8, 12 and 20 weeks of age. Health status was tracked weekly. At weaning (20 weeks), foals were divided into three health groups: (1) foals that remained healthy, (2) foals that developed subclinical, self-resolving pneumonia and (3) foals that developed clinically apparent pneumonia necessitating antimicrobial treatment. Foals were randomly selected (n = 30/group) for cortisol, vitamin D and cytokine (TNFα, IL-4, IL-10, IL-17 and interferon-gamma [IFN-γ]) analysis using validated assays.
resultsWe observed disease-associated differences for IFN-γ at 4 weeks (χ MAIN LIMITATIONS: Causative agent not identified, frequency and timing of sample collection may have impacted results, and systemic cytokine concentrations may not accurately reflect cytokine availability and activity at the tissue level.
conclusionsPeriodic measurement of circulating steroid hormones and cytokines from birth to weaning was not predictive of pneumonia susceptibility and severity in foals on a farm with endemic pneumonia. Disease-associated IFN-γ differences warrant further investigation.
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