Evidence map›Paper›PMID 40923205›Full record

ArticleAdvanced healthcare materials2026

Borate-Ion-Stimulated Macrophages Promote Osteogenic Differentiation of Mesenchymal Stem Cells.

Kazumasa Ikedo, Hiroki Hatakeyama, Sayaka Oguri, Akiko Obata, Toshihiro Kasuga

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kazumasa IkedoGraduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan.
Hiroki HatakeyamaGraduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan.
Sayaka OguriGraduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan.
Akiko ObataGraduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan.
Toshihiro KasugaGraduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan.ORCID 0000-0002-8745-8932

Funding

Japan Society for the Promotion of Science 20H00304Japan Society for the Promotion of Science 24KK0204Japan Society for the Promotion of Science JPJSBP120235703
6 · The paper itself

Abstract

Immune cells, such as macrophages, stimulated by several types of inorganic ions released from bioactive glasses secrete cytokines that promote and inhibit bone formation. In this study, the effects of borate-ion-stimulated mouse macrophages (RAW264) on the osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells (KUSA-A1) are investigated. KUSA-A1 is cultured with a borate-ion-containing medium and RAW264-conditioned medium, which contained the secretome released from boron-stimulated RAW264, and its osteogenic differentiation is evaluated. Results indicated that the secretome of RAW264 stimulated by more than 3 mg L

Indexed as

BoratesCell DifferentiationMacrophagesMesenchymal Stem CellsOsteogenesisAnimalsCulture Media, ConditionedIonsMiceRAW 264.7 CellsBoratesCulture Media, ConditionedIonsborate ionmacrophagesmesenchymal stem cellsmineralization

Identifiers

PMID40923205
PMCPMC12805609

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.