Evidence map›Paper›PMID 40923669›Full record

ArticleCytoskeleton (Hoboken, N.J.)2026

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane-Fly Spermatocytes.

Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo-Valdur Mikelsaar, Arthur Forer, Rose Sheykhani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The chromosome complement of malemicroPublication biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Demetra EconomopoulosDepartment of Biology, York University, Toronto, Canada.
Maral JananDepartment of Biology, York University, Toronto, Canada.
Martina KrügerInstitute of Cardiovascular Physiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Aavo-Valdur MikelsaarThe Institute of Biomedicine and Translational Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.
Arthur ForerDepartment of Biology, York University, Toronto, Canada.
Rose SheykhaniDepartment of Biology, Lakeland Community College, Kirtland, Ohio, USA.ORCID https://orcid.org/0009-0000-3136-6425

Funding

German Research Foundation CRC1116-TP A02Johns Hopkins UniversityNatural Sciences and Engineering Research Council of Canada RGPIN-2019-06299
6 · The paper itself

Abstract

Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane-fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin "strands" extend between separating chromosomes, connecting their telomeres, just as tethers do. Since titin is responsible for elastic forces in myofibrils, we suggest that titin is responsible for the backwards forces exerted on chromosome arms during anaphase.

Indexed as

AnaphaseConnectinDipteraSpermatocytesAnimalsMaleConnectinchromosomesconnectin (titin)fluorescent antibody techniquemeiosismitotic tethersmyofibrilsanaphase

Identifiers

PMID40923669
PMCPMC13340505

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.