ArticlePhysiological reports2025
Beetroot leaf extract enhances gut motility in a model of loperamide-induced constipation in male rats: A phytopharmacological study.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Untargeted LC-QTOF-MS/MS metabolomics and integrative pharmacology identify candidate triterpenoids associated with the gastrointestinal activity of Baliospermum montanum root extract.Inflammopharmacology · 2026Article
- Beetroot leaf extract enhances gut motility in a model of loperamide-induced constipation in male rats: A phytopharmacological study.Physiological reports · 2025Article
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6 authors.
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Abstract
Constipation is a common gastrointestinal disorder characterized by infrequent and difficult bowel movements, hard stool consistency, and delayed intestinal transit. The present study evaluated the phytochemical profile and physiological effects of the aqueous extract of beetroot leaves (AEBL) in a rat model of Loperamide (LOP)-induced constipation. Thirty-six male Wistar rats were randomly assigned to six groups (n = 6): two controls (normal and constipated) and four constipated groups receiving either increasing doses of AEBL (100, 200, or 400 mg/kg, b.w.) or yohimbine (YOH; 2 mg/kg, b.w.) as a reference prokinetic agent. Treatments were administered orally 1 h after LOP intoxication for seven consecutive days. The phytochemical screening revealed that AEBL is rich in polyphenols, flavonoids, and betalains. Antioxidant assays (DPPH and ABTS) demonstrated strong radical scavenging activity. In vivo, the oral administration of AEBL showed no signs of toxicity or abnormal behavior in rats, with an LD
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