ArticleEuropean journal of heart failure2025
Distinct blood volume and left ventricular adaptation to severe obesity in middle-aged adults at risk for heart failure.
Article in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Adipokine profile in acute heart failure: associations with natriuretic response and prognosis.ESC heart failure · 2026Observational
- Triglyceride-glucose index and mortality in critically ill patients with cardiovascular-kidney-metabolic syndrome stage 4.Cardiovascular diabetology · 2026Article
- Adult weight change across the life course and cardiovascular disease prevalence and mortality: a population-based study.Frontiers in public health · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
aimsObesity is commonly hypothesized to lead to the development of heart failure (HF) in part due to increases in blood volume (BV) and left ventricular (LV) remodelling. Whether adiposity and obesity severity are associated with BV expansion and subsequent LV remodelling in middle-aged individuals at increased risk (IR) prior to the onset of HF is unknown. METHODS AND
resultsWe analysed data from 96 middle-aged (40-64 years) non-obese (25.8 [23.6-28.6] kg/m
conclusionsWhile lean mass is the primary determinant of BV, fat mass is independently associated with BV expansion and larger LVEDV. IR adults with class II/III obesity display distinct LV enlargement that is disproportionate to body size (i.e. LVEDV index) and may represent a physiologically distinct subgroup of obesity as opposed to a simple continuum of disease severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.