ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Detection and pharmacokinetics of licochalcone A in brains of neuroinflammatory mouse model.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Licochalcone A (LCA), a natural flavonoid with potent anti-inflammatory properties, has shown promise as a neuroprotective agent. However, its ability to cross the blood-brain barrier (BBB) and exert central effects remains underexplored. In this study, we demonstrate for the first time that LCA enhances cognitive function in a lipopolysaccharide (LPS)-induced neuroinflammatory mouse model and effectively penetrates the BBB. Following intraperitoneal administration of LCA (20 mg/kg), behavioral assessments via novel object recognition and Y-maze tests revealed significant improvements in non-spatial and spatial short-term memory. To investigate whether LCA is able to cross the BBB, we first developed and validated a sensitive GC-MS/MS method (LOD, 0.14 µg/mL; LOQ, 0.42 µg/mL) capable of quantifying LCA in brain tissue. The method revealed LCA brain concentrations peaking at 4 h (T
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