SynthesisLangenbeck's archives of surgery2025
The role of remote ischaemic preconditioning (RIPC) in colorectal surgery: a meta-analysis of randomized-controlled studies.
Synthesis in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRemote ischaemic preconditioning (RIPC) which consists of repeated brief episodes of non-lethal limb ischaemia is associated with organ protection and improved clinical outcomes through complex pathophysiological pathways. The aim of this meta-analysis was to evaluate the postoperative effects of RIPC in bowel recovery and surgical morbidity after colorectal surgery.
methodsIn strict adherence to the PRISMA guidelines, a systematic literature search was performed for studies comparing the postoperative effect RIPC in colorectal surgery. Data from eligible studies were extracted, qualitatively assessed, and included. Odds ratios (OR) and standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated.
resultsFour studies with a total of 311 patients were included. RIPC resulted in reduced rates of postoperative ileus (POI) (OR 0.42, 95% CI 0.21-0.85, p = 0.02) and lower postoperative TNF-α levels (SMD - 1.01, 95% CI -1.59,-0.43, p = 0.0007). There were no significant differences between the two groups in other clinical outcomes such as anastomotic leak, surgical morbidity and length of hospital stay.
conclusionsRIPC demonstrated significantly reduced POI rates and TNF-α levels in colorectal surgery and could be a potential supportive strategy to promote less tissue trauma and thus enhance bowel recovery. Larger randomized controlled trials with standardized study protocols are needed to validate the results presented here.
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