Evidence map›Paper›PMID 40924359›Full record

ArticleJournal of biomolecular NMR2025

An optimized

Tairan Yuwen, Jiangshu Liu, Zhilian Xia, Youlin Xia, Paolo Rossi, Charalampos G Kalodimos

Abstract read
In one paragraph

Article in Journal of biomolecular NMR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tairan YuwenDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. tyuwen@stjude.org.ORCID http://orcid.org/0000-0003-3504-7995
Jiangshu LiuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Zhilian XiaDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Youlin XiaDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID http://orcid.org/0000-0001-7255-5425
Paolo RossiDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID http://orcid.org/0000-0001-8178-0122
Charalampos G KalodimosDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. babis.kalodimos@stjude.org.ORCID http://orcid.org/0000-0001-6354-2796

Funding

Structure and functional mechanisms of molecular chaperones and protein kinasesR35GM122462 · NIGMS · UNIVERSITY OF MINNESOTA · PI CHARALAMPOS KALODIMOS · 2017 to 2026
$6.8M
Natural Science Foundation of Beijing Municipality 7232251NIGMS NIH HHS R35 GM122462NIH HHS R35 GM122462
6 · The paper itself

Abstract

Biomolecular dynamics in the microsecond-to-millisecond (µs-ms) timescale are linked to various biological functions, such as enzyme catalysis, allosteric regulation, and ligand recognition. In solution state NMR, Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion experiments are commonly used to probe µs-ms timescale motions, providing detailed kinetic, thermodynamic, and mechanistic information at the atomic level. For investigating conformational dynamics in high-molecular-weight biomolecules, methyl groups serve as ideal probes due to their favorable relaxation properties, and

Indexed as

Nuclear Magnetic Resonance, BiomolecularProteinsCarbon IsotopesKineticsMolecular Dynamics SimulationProtein ConformationCarbon-13Carbon IsotopesProteinsBiomolecular dynamicsConformational exchangeCPMGInvisible excited statesMethyl NMRPhase cycleRelaxation dispersion

Identifiers

PMID40924359
PMCPMC12790411

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.