Evidence map›Paper›PMID 40924445›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Adrenal lipoma formation via PI(3,4,5)P

Shogo Yanai, Junko Sasaki, Hyeon-Cheol Lee-Okada, Fumiya Takahashi, Yuto Kikuchi, Shin Morioka, Toshiyoshi Yamamoto, Katsuya Yuguchi, Miko Oikawa, Hiroaki Kajiho and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Adrenal lipoma formation via PI(3,4,5)PProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shogo YanaiDepartment of Biochemical Pathophysiology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Junko SasakiDepartment of Biochemical Pathophysiology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Hyeon-Cheol Lee-OkadaDepartment of Biochemistry, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID 0000-0002-5493-8112
Fumiya TakahashiDepartment of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.ORCID 0009-0007-9006-4831
Yuto KikuchiDepartment of Biochemical Pathophysiology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Shin MoriokaDepartment of Biochemical Pathophysiology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.ORCID 0000-0002-7702-0937
Toshiyoshi YamamotoDepartment of Biochemical Pathophysiology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Katsuya YuguchiDepartment of Biochemical Pathophysiology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Miko OikawaDepartment of Biochemical Pathophysiology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Hiroaki KajihoDepartment of Biochemical Pathophysiology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.ORCID 0000-0001-6376-7629
Takashi BabaDepartment of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.ORCID 0000-0001-8767-9877
Chikako YokoyamaDepartment of Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, Sumiyoshi-ku, Osaka 558-8585, Japan.ORCID 0000-0002-9219-8661
Ken-Ichirou MorohashiDepartment of Internal Medicine, Kurume University School of Medicine, Asahimachi, Kurume, Fukuoka 830-0011, Japan.
Akira SuzukiDivision of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Hyogo 650-0047, Japan.ORCID 0000-0002-5950-8808
Takehiko YokomizoDepartment of Biochemistry, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID 0000-0002-5219-1553
Takehiko SasakiDepartment of Biochemical Pathophysiology, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.ORCID 0000-0003-1837-3748

Funding

Japan Agency for Medical Research and Development (AMED) 24gm1710007MEXT JPMXP1323015483
6 · The paper itself

Abstract

Adrenal lipomas are benign tumors containing ectopic adipose tissue in the adrenal gland, an organ that normally lacks both adipocytes and their progenitors. The origin of this ectopic fat remains enigmatic, and the absence of a genetic animal model has hindered its investigation. Phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P

Indexed as

AdipocytesAdrenal CortexAdrenal Gland NeoplasmsCell TransdifferentiationLipomaPhosphatidylinositol PhosphatesProto-Oncogene Proteins c-aktAnimalsMicePPAR gammaPTEN PhosphohydrolaseSignal Transductionphosphatidylinositol 3,4,5-triphosphatePhosphatidylinositol PhosphatesPPAR gammaProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePten protein, mouseadipocyteadrenal lipomaphosphoinositidephospholipidtransdifferentiation

Identifiers

PMID40924445
PMCPMC12452946

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.