Evidence map›Paper›PMID 40924618›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Microvascular preservation and cardiomyocyte hyperplasia underlie adaptive right ventricle development in congenital heart disease-pulmonary arterial hypertension.

Michael A Smith, Eleana S Guardado, Jason Boehme, Sanjeev A Datar, Emin Maltepe, Naveen Swami, Gary W Raff, Aaron Bodansky, Prakash Chelladurai, Joseph Moreno and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michael A SmithDivision of Pediatric Critical Care, Department of Pediatrics, University of California, San Francisco, California, United States.ORCID 0000-0002-7899-7248
Eleana S GuardadoDivision of Pulmonary, Allergy, and Critical Care Medicine, Wall Center for Cardiopulmonary Research, Stanford University, Stanford, California, United States.
Jason BoehmeDivision of Pediatric Critical Care, Department of Pediatrics, University of California, San Francisco, California, United States.ORCID 0000-0003-4908-9934
Sanjeev A DatarDivision of Pediatric Critical Care, Department of Pediatrics, University of California, San Francisco, California, United States.ORCID 0009-0003-6986-2821
Emin MaltepeDivision of Neonatology, Department of Pediatrics, University of California, San Francisco, California, United States.
Naveen SwamiDivision of Pediatric Cardiothoracic Surgery, Department of Surgery, University of California, San Francisco, California, United States.
Gary W RaffDivision of Pediatric Cardiothoracic Surgery, Department of Surgery, University of California, Davis, California, United States.ORCID 0000-0001-8118-630X
Aaron BodanskyDivision of Pediatric Critical Care, Department of Pediatrics, University of California, San Francisco, California, United States.
Prakash ChelladuraiDivision of Pulmonary, Allergy, and Critical Care Medicine, Wall Center for Cardiopulmonary Research, Stanford University, Stanford, California, United States.
Joseph MorenoDepartment of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, United States.
Annelise Renee PrinceDepartment of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, United States.
Nevan PowersDepartment of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, United States.
Guo N HuangDepartment of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, United States.
Vinicio de Jesus PerezDivision of Pulmonary, Allergy, and Critical Care Medicine, Wall Center for Cardiopulmonary Research, Stanford University, Stanford, California, United States.
Jeffrey R FinemanDivision of Pediatric Critical Care, Department of Pediatrics, University of California, San Francisco, California, United States.

Funding

TGF-ß-SOX18-Collagen metabolism in pulmonary vascular disease associated with CHDP01HL146369 · NHLBI · UNIVERSITY OF ARIZONA · PI Stephen M Black · 2020 to 2026
$18.7M
Altered Lymphatic Function and Development in Congenital Heart DiseaseR01HL133034 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sanjeev A. Datar · 2016 to 2026
$6.4M
Molecular control of cardiac regenerative potentialR01HL138456 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Guo Huang · 2018 to 2026
$5.1M
The Wnt7a/ROR2 axis in the pathogenesis of pulmonary arterial hypertensionR01HL134776 · NHLBI · STANFORD UNIVERSITY · PI DE JESUS PEREZ, VINICIO A · 2017 to 2025
$5.0M
Endothelial-pericyte interactions in the pathogenesis of pulmonary arterial hypertensionR01HL139664 · NHLBI · STANFORD UNIVERSITY · PI DE JESUS PEREZ, VINICIO A · 2018 to 2025
$4.7M
Multidisciplinary Research Training in Pediatric Pulmonary Vascular DiseaseT32HL160508 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Steven Herbert Abman, Eric Douglas Austin · 2022 to 2026
$1.7M
The Role of the CES1 in the Pathogenesis of Pulmonary Arterial HypertensionR01HL172449 · NHLBI · STANFORD UNIVERSITY · PI VINICIO A DE JESUS PEREZ · 2024 to 2026
$1.6M
Pulmonary vascular glutamine metabolism at the intersection of hemodynamic forces and smooth muscle proliferation in congenital heart diseaseK08HL148512 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOEHME, JASON · 2020 to 2024
$874k
American Heart Association (AHA) Established Investigator AwardHHS | National Institutes of Health (NIH) 5R01HL172449-02HHS | National Institutes of Health (NIH) K08HL148512HHS | National Institutes of Health (NIH) P01HL146369HHS | National Institutes of Health (NIH) R01HL133034HHS | National Institutes of Health (NIH) R01HL134776HHS | National Institutes of Health (NIH) R01HL138456HHS | National Institutes of Health (NIH) R01HL139664HHS | National Institutes of Health (NIH) R01HL157280HHS | National Institutes of Health (NIH) R01HL59886HHS | National Institutes of Health (NIH) T32HL160508-01A1NHLBI NIH HHS K08 HL148512NHLBI NIH HHS L40 HL181844NHLBI NIH HHS P01 HL146369NHLBI NIH HHS R01 HL133034NHLBI NIH HHS R01 HL134776NHLBI NIH HHS R01 HL138456NHLBI NIH HHS R01 HL139664NHLBI NIH HHS R01 HL172449NHLBI NIH HHS T32 HL160508Tobacco-Related Disease Research Program (TRDRP) P0558275
6 · The paper itself

Abstract

Right ventricular (RV) failure is the primary cause of death among patients with pulmonary arterial hypertension (PAH). Patients with congenital heart disease-associated PAH (CHD-PAH) demonstrate improved outcomes compared with patients with other forms of PAH, which is related to the maintenance of an adaptively hypertrophied RV. In an ovine model of CHD-PAH, we aimed to elucidate the cellular, microvascular, and transcriptional adaptations to congenital pressure overload that support RV function. Fetal surgery was performed on late gestation lambs to insert an aortopulmonary graft, leading to a persistent congenital left-right shunt and RV pressure load. At 3 days and 4-6 wk of life, shunt RV myocardial structure, growth mechanisms, and transcriptomes were compared with age-matched control and unoperated fetal RV. At 4-6 wk of age, shunt lambs demonstrate significant RV enlargement (shunt 37.1 ± 7.6 g vs. control 15.9 ± 1.9 g,

Indexed as

Heart Defects, CongenitalHeart VentriclesHypertension, PulmonaryHypertrophy, Right VentricularMicrovesselsMyocytes, CardiacPulmonary Arterial HypertensionVentricular Function, RightVentricular RemodelingAdaptation, PhysiologicalAnimalsCell ProliferationDisease Models, AnimalFemaleHyperplasiaSheepcongenital heart diseasepulmonary hypertensionright ventricle

Identifiers

PMID40924618
PMCPMC12478462

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.