Evidence map›Paper›PMID 40924818›Full record

ArticleScience signaling2025

Samuel J Mabry, Xixi Cao, Yanqi Zhu, Caleb Rowe, Shalin Patel, Camila González-Arancibia, Tiziana Romanazzi, David P Saleeby, Anna Elam, Hui-Ting Lee and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. GutGut microbes · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

17 authors.

Samuel J MabryDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0003-4856-4481
Xixi CaoSchool of Dentistry, Oregon Health & Science University, Portland, OR 97201, USA.ORCID 0000-0002-9737-6172
Yanqi ZhuDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-8631-0784
Caleb RoweDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-0008-1651
Shalin PatelDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL 35233, USA.
Camila González-ArancibiaDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL 35233, USA.ORCID 0009-0005-8985-0099
Tiziana RomanazziDepartment of Biotechnology and Life Sciences, University of Insubria, Varese 21100, Italy.ORCID 0000-0001-5185-5015
David P SaleebyDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL 35233, USA.
Anna ElamDepartment of Psychiatry, University of Alabama Birmingham, Birmingham, AL 35233, USA.
Hui-Ting LeeDepartment of Chemistry, University of Alabama Birmingham, Birmingham, AL 35205, USA.ORCID 0000-0002-2648-4053
Serhat TurkmenDepartment of Cell, Developmental, and Integrative Biology, Howard Hughes Medical Institute, University of Alabama Birmingham, Birmingham, AL 35233, USA.
Shelby N LauzonDepartment of Cell, Developmental, and Integrative Biology, Howard Hughes Medical Institute, University of Alabama Birmingham, Birmingham, AL 35233, USA.ORCID 0009-0004-0751-9697
Cesar E HernandezDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL 35233, USA.ORCID 0009-0009-7058-8552
HaoSheng SunDepartment of Cell, Developmental, and Integrative Biology, Howard Hughes Medical Institute, University of Alabama Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0003-3919-559X
Hui WuSchool of Dentistry, Oregon Health & Science University, Portland, OR 97201, USA.ORCID 0000-0003-1694-3954
Angela M CarterDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0001-5766-3743
Aurelio GalliDepartment of Surgery, University of Alabama Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0001-7173-9345

Funding

The Role of Microbiome Composition in Amphetamine AbuseR01DA056484 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Angela Michelle Carter, AURELIO GALLI · 2023 to 2026
$2.2M
Microbial Biofilms as Regulators of Amphetamine Use DisordersR21DA059844 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARTER, ANGELA MICHELLE, VELU, SADANANDAN E. · 2024 to 2025
$408k
NIDA NIH HHS R01 DA056484NIDA NIH HHS R21 DA059844
6 · The paper itself

Abstract

Amphetamines are psychostimulants that are commonly used to treat neuropsychiatric disorders and are prone to misuse. The pathogenesis of amphetamine use disorder (AUD) is associated with dysbiosis (an imbalance in the body's microbiome) and bacterially produced short-chain fatty acids (SCFAs), which are implicated in the gut-brain axis. Amphetamine exposure in both rats and humans increases the amount of intestinal

Indexed as

AmphetamineAmphetamine-Related DisordersBehavior, AnimalButyratesEpigenesis, GeneticFusobacterium nucleatumAnimalsDopamineDopamine Plasma Membrane Transport ProteinsDrosophila melanogasterGastrointestinal MicrobiomeMaleAmphetamineButyratesDopamineDopamine Plasma Membrane Transport Proteins

Identifiers

PMID40924818
PMCPMC13237861

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.