Evidence map›Paper›PMID 40925285›Full record

ArticleNuclear medicine and biology

L-5-[

Christopher T Hensley, Prashanth Padakanti, Raheema Damani, Christina Dulal, Hoon Choi, Shihong Li, Jianbo Cao, Hsiaoju Lee, Austin Pantel, Elizabeth Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Metabolic Imaging and Molecular Signatures Reveal Metabolic Phenotypes in Recurrent Glioblastoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christopher T HensleyDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Prashanth PadakantiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Raheema DamaniDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Christina DulalDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Hoon ChoiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Shihong LiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Jianbo CaoCancer Research UK, University of Cambridge, Cambridge, UK.
Hsiaoju LeeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Austin PantelDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Elizabeth LiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
David MankoffDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: david.mankoff@pennmedicine.upenn.edu.
Rong ZhouDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Funding

RESEARCH TRACK RADIOLOGY RESIDENCYT32EB004311 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Terence P Gade, Misun Hwang · 2005 to 2026
$4.5M
PET Imaging of Glutamine Metabolism and Glutamate Transport to Guide Metabolically Targeted Therapy in Triple-Negative Breast CancerR01CA266285 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVID A. MANKOFF, Rong Zhou · 2022 to 2026
$2.6M
Molecular Imaging Markers for Glutaminolysis in Breast CancerR01CA211337 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MANKOFF, DAVID A., ZHOU, RONG · 2017 to 2021
$2.0M
NCI NIH HHS R01 CA211337NCI NIH HHS R01 CA266285NIBIB NIH HHS T32 EB004311
6 · The paper itself

Abstract

backgroundGlutamine is an important metabolic substrate in many aggressive tumors, with comparable importance to glucose metabolism. Utilizing human breast cancer mouse xenograft models, we studied the kinetics of the PET imaging agent, L-5-[

methodsThe study used xenograft mouse models for two breast cancer cell lines, HCC1806, a highly glutaminolytic triple-negative cell line, and MCF-7, a hormone receptor positive line with only low levels of glutaminolysis. Mice were injected with [

resultsWe found that, out to 30 min post-injection, the majority of radioactivity in highly glutaminolytic tumors (HCC1806) was in the form of [

conclusionOur studies on [

Indexed as

Breast NeoplasmsCarbon RadioisotopesGlutaminePositron-Emission TomographyAnimalsCell Line, TumorDisease Models, AnimalFemaleGlutaminaseHumansMiceCarbon-11Carbon RadioisotopesGlutaminaseGlutamineCancerGlutaminaseL-5-[(11)C]-glutamateL-5-[(11)C]-glutamineMetabolism

Identifiers

PMID40925285
PMCPMC13070223

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.