Evidence mapPaperPMID 40925674Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Sphingosine-1-Phosphate Signaling through Müller Glia Regulates Neuroprotection, Accumulation of Immune Cells, and Neuronal Regeneration in the Rodent Retina.

Olivia Taylor, Lisa E Kelly, Heithem M El-Hodiri, Andy J Fischer

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Olivia TaylorDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio 43210.
Lisa E KellyDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio 43210.
Heithem M El-HodiriDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio 43210.
Andy J FischerDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, Ohio 43210 andrew.fischer@osumc.edu.

Funding

Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cellsR01EY032141 · NEI · OHIO STATE UNIVERSITY · 2022 to 2025
$1.5M
NEI NIH HHS R01 EY032141
6 · The paper itself

Abstract

The purpose of this study was to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, neuroprotection, and reprogramming of Müller glia (MG) into neurogenic MG-derived progenitor cells (MGPCs) in the adult male and female mouse retina. We found that S1P-related genes were dynamically regulated following retinal damage.

Indexed as

Ependymoglial CellsLysophospholipidsNerve RegenerationNeuroprotectionRetinaSignal TransductionSphingosineAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPhosphotransferases (Alcohol Group Acceptor)Sphingosine-1-Phosphate ReceptorsSphingosine KinaseLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)S1pr1 protein, mouseSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate ReceptorsSphingosine Kinaseimmune cell recruitmentMG-derived progenitor cells (MGPCs)Müller gliaNFκB signalingretinal injurysphingosine-1-phosphate (S1P)

Identifiers

PMID40925674
PMCPMC12548709

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.