Evidence map›Paper›PMID 40925758›Full record

ReviewSeminars in nephrology2025

A Holistic Approach to AKI: Integrating Clinical and Molecular Data in the Human Kidney.

Jennifer A Schaub, Mathew Alaba, Matthias Kretzler

Abstract readReview
In one paragraph

Review in Seminars in nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer A SchaubDivision of Nephrology, Internal Medicine, University of Michigan, Ann Arbor, MI.
Mathew AlabaDivision of Nephrology, Internal Medicine, University of Michigan, Ann Arbor, MI.
Matthias KretzlerDivision of Nephrology, Internal Medicine, University of Michigan, Ann Arbor, MI. Electronic address: kretzler@umich.edu.

Funding

Central Hub for Kidney Precision MedicineU24DK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$21.1M
ConProject-002U2CDK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, IYENGAR, SRINIVAS RAVI V · 2017 to 2021
$21.0M
University of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PENNATHUR, SUBRAMANIAM · 2008 to 2022
$12.9M
KPMP Kidney Mapping and Atlas Project (KMAP)U01DK133090 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$10.4M
PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)U01DK114907 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nir Hacohen, Jeffrey Benton Hodgin · 2022 to 2026
$3.2M
Cleveland Precision Medicine Chronic Kidney Disease CohortU01DK114908 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI JOHN F. O'TOOLE, EMILIO DANIEL POGGIO · 2022 to 2026
$2.2M
A Systems Biology and Patient Stratification Approach to Improve Outcomes of Patients with Hypoxic Injury in Renal Tubular Cells in Chronic Kidney DiseasesK08DK124449 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHAUB, JENNIFER ANN · 2020 to 2024
$847k
A systems biology approach to identify cortical and medullary gene regulatory networks related to Hypoxia Inducible Factor-1AR03DK138962 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jennifer Ann Schaub · 2025 to 2026
$234k
NIDDK NIH HHS K08 DK124449NIDDK NIH HHS P30 DK081943NIDDK NIH HHS R03 DK138962NIDDK NIH HHS U01 DK114907NIDDK NIH HHS U01 DK114908NIDDK NIH HHS U01 DK133090NIDDK NIH HHS U24 DK114886NIDDK NIH HHS U2C DK114886
6 · The paper itself

Abstract

Despite intensive research efforts, acute kidney injury (AKI) is a common clinical syndrome that has limited treatment options apart from supportive care. The increasing availability of molecular interrogation data from patients with Acute Kidney Injury provides an unparalleled opportunity to leverage systems biology approaches. In this review, we discuss the challenges with AKI research, explain how systems biology approaches can link molecular data to clinical phenotypes, review available molecular interrogation tools and techniques, and provide examples where systems biology approaches have been successfully applied in nephrology.

Indexed as

Acute Kidney InjurySystems BiologyHumansKidneyPhenotypeAcute kidney injuryepigenomicsmetabolomicsproteomicssystems biologytranscriptomics

Identifiers

PMID40925758
PMCPMC12435924

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.