Evidence map›Paper›PMID 40926045›Full record

ArticleOncogene2025

Extracellular vesicles of cancer cells induce FOXP3+ fibroblasts and facilitate tumor invasion via the Wnt3-β-catenin pathway.

Tomoaki Kimura, Kurara Takagane, Go Itoh, Sei Kuriyama, Kenji Meguro, Souichi Koyota, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Shuichi Tsukamoto and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tomoaki KimuraDepartment of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Akita, Japan.
Kurara TakaganeDepartment of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Akita, Japan.
Go ItohDepartment of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Akita, Japan.
Sei KuriyamaDepartment of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Akita, Japan.ORCID 0000-0002-5502-7177
Kenji MeguroBioscience Education and Research Support Center, Akita University, Akita, Japan.
Souichi KoyotaBioscience Education and Research Support Center, Akita University, Akita, Japan.
Masami YamamotoLaboratory of Physiological Pathology, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo, Japan.ORCID 0000-0003-2071-7730
Tetsuya TsukamotoDivision of Analytical Pathology, Oncology Innovation Center, Fujita Health University, Toyoake, Aichi, Japan.
Sachiyo NomuraDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID 0000-0003-4293-6205
Shuichi TsukamotoDepartment of Pathology, Division of Molecular and Genomic Pathology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan.
Naozane NomuraDepartment of Pathology, Division of Molecular and Genomic Pathology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan.ORCID 0009-0007-0700-058X
Masafumi HorieDepartment of Pathology, Division of Molecular and Genomic Pathology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan.
Motonobu SaitoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.ORCID 0000-0001-5072-3520
Akiteru GotoDepartment of Cellular and Organ Pathology, Akita University Graduate School of Medicine, Akita, Japan.ORCID 0000-0001-8776-9004
Masakazu YashiroDepartment of Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Junichi AritaDepartment of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Masamitsu TanakaDepartment of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Akita, Japan. mastanak@med.akita-u.ac.jp.ORCID 0000-0002-4823-9737

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 22H02897MEXT | Japan Society for the Promotion of Science (JSPS) 22K07163MEXT | Japan Society for the Promotion of Science (JSPS) 23K18307
6 · The paper itself

Abstract

Forkhead-box-protein P3 (FOXP3) is a key transcription factor in T regulatory cells (Tregs). However, its expression and significance in non-immune stromal cells in the tumor microenvironment remain unclear. Here, we demonstrated FOXP3 expression in stromal fibroblasts of mouse and human gastrointestinal tumors. Immunohistological examination revealed FOXP3 expression in αSMA

Indexed as

beta CateninExtracellular VesiclesFibroblastsForkhead Transcription FactorsStomach NeoplasmsWnt Signaling PathwayAnimalsCell Line, TumorHumansMiceNeoplasm InvasivenessNIH 3T3 CellsT-Lymphocytes, RegulatoryTumor Microenvironmentbeta CateninForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouse

Identifiers

PMID40926045

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.