ReviewNature aging2025
Emerging strategies, applications and challenges of targeting NAD
Abstract readReview
In one paragraph
Review in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Laser-Engineered Ag Nanoparticle on Carbon Cloth Electrodes for Enzyme-Free Electrochemical NADSmall (Weinheim an der Bergstrasse, Germany) · 2026Article
- Mitochondrial quality control in human ageing and longevity.Nature metabolism · 2026Review
- Mitochondrial Quality Control in Age-Related Diseases: From Molecular Architecture to Precision Therapeutics.Antioxidants (Basel, Switzerland) · 2026Review
- Transcriptional Profiling Shows Dampening of Interferon Gene Signatures by NADInternational journal of molecular sciences · 2026Article
- Nicotinamide riboside prevents mitochondrial dysfunction in nemaline myopathy type 6.Human molecular genetics · 2026Article
- Human whole-blood NADNature metabolism · 2026Article
- Whole-blood NADNature metabolism · 2026Article
- An integrated anti-aging framework targeting NADRedox biology · 2026Review
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Organelle resilience as a comparative blueprint for longevity.EMBO molecular medicine · 2026Review
- The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK-SARM1-ULK1 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dietary restriction in aging and longevity.Nature aging · 2026Review
- Perturbation of NAD(P)H metabolism with theScience advances · 2026Article
- Intravenous infusion of nicotinamide adenine dinucleotide (NADFrontiers in aging · 2026Article
- Changes in the brain [NADFrontiers in aging neuroscience · 2026Review
- From autophagy-lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders.Frontiers in neuroscience · 2026Review
- NADScience advances · 2025Article
- From Bench to Clinic: The 2024 FASEB Scientific Research Conference on NAD Metabolism and Signaling.Molecular medicine (Cambridge, Mass.) · 2025Article
- Identification of potential biomarkers for breast cancer based on salivary metabolomics.Frontiers in oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Jianying Zhang *Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.ORCID http://orcid.org/0000-0001-8161-7536
He-Ling Wang *Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.ORCID http://orcid.org/0000-0002-8920-1487
Sofie LautrupDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.ORCID http://orcid.org/0000-0002-6632-7853
Hilde Loge NilsenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-2115-2663
Jonas T TreebakNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1488-7012
Leiv Otto WatneInstitute of Clinical Medicine, Campus Ahus, University of Oslo, Lørenskog, Norway.ORCID http://orcid.org/0000-0003-0441-6700
Geir SelbækInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-6511-8219
Lindsay E WuSchool of Biomedical Sciences, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-1599-7574
Torbjørn OmlandDepartment of Cardiology, Akershus University Hospital, Lørenskog, Norway.ORCID http://orcid.org/0000-0002-6452-0369
Eija PirinenResearch Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0003-1495-3972
Tin Cho CheungHong Kong Longevity Science Laboratory Limited, Hong Kong Science Park, Pak Shek Kok, Hong Kong SAR, China.
Jun WangHong Kong Longevity Science Laboratory Limited, Hong Kong Science Park, Pak Shek Kok, Hong Kong SAR, China.
Mathias ZieglerDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0001-6961-2396
Ole-Bjørn TysnesDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-7230-6426
Rubén Zapata-PérezGroup of Metabolism and Gene Regulation, UCAM HiTech Sport & Health Innovation Hub, Universidad Católica de Murcia, Guadalupe de Maciascoque, Murcia, Spain.ORCID http://orcid.org/0000-0003-4432-9652
Santina BruzzoneDepartment of Experimental Medicine, Section of Biochemistry, University of Genova, Genova, Italy.ORCID http://orcid.org/0000-0003-2034-3716
Carles CantoLaboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-5167-7922
Michela DeleidiMechanisms and Therapy of Genetic Brain Diseases Institut Imagine, INSERM UMR 1163- Paris Cite' University, Paris, France.ORCID http://orcid.org/0000-0003-0357-0124
Georges E JanssensLaboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology, and Metabolism (AGEM), Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2104-8145
Riekelt H HoutkooperLaboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology, and Metabolism (AGEM), Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9961-0842
Morten Scheibye-KnudsenCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6637-1280
Masaya KoshizakaDepartment of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID http://orcid.org/0000-0001-7374-9993
Koutaro YokoteDepartment of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID http://orcid.org/0000-0003-3033-4813
Eric VerdinUCSF Department of Medicine, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3703-3183
Vilhelm A BohrCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4823-6429
Charalampos TzoulisDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-0341-5191
David A SinclairDepartment of Genetics, Blavatnik Institute, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9936-436X
Evandro Fei FangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway. e.f.fang@medisin.uio.no.ORCID http://orcid.org/0000-0003-0355-7202
Funding
Alzheimer's Association PTC-Gene-25-1439553Bergens Forskningsstiftelse (Bergen Research Foundation) BFS2017REK05Compagnia di San Paolo (Fondazione Compagnia di San Paolo) Bando TrapezioCure Alzheimer's Fund (Alzheimer's Disease Research Foundation) 282952Cure Alzheimer's Fund (Alzheimer's Disease Research Foundation) 284930Fondation de France 00147852 / WB-2023-51647Helse Vest (Western Norway Regional Health Authority) F-10229-D11661Japan Agency for Medical Research and Development (AMED) JP21bm0804016Japan Agency for Medical Research and Development (AMED) JP21jm0210096Japan Agency for Medical Research and Development (AMED) JP22ym0126066Japan Agency for Medical Research and Development (AMED) JP23ek0109622Michael J. Fox Foundation for Parkinson's Research (Michael J. Fox Foundation) 022355Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 2017095Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 2021021Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 2023093Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 272931Ministry of Health, Labour and Welfare (Ministry of Health, Labour and Welfare, Japan) JPMH21FC1016National Natural Science Foundation of China (National Science Foundation of China) 81971327NordForsk 119986Norges Forskningsråd (Research Council of Norway) 262175Norges Forskningsråd (Research Council of Norway) 288164Norges Forskningsråd (Research Council of Norway) 302314)Norges Forskningsråd (Research Council of Norway) 302483Norges Forskningsråd (Research Council of Norway) 309567Norges Forskningsråd (Research Council of Norway) 325172Norges Forskningsråd (Research Council of Norway) 326461Norges Forskningsråd (Research Council of Norway) 332713Norges Forskningsråd (Research Council of Norway) 334361Novo Nordisk Foundation Center for Basic Metabolic Research (NovoNordisk Foundation Center for Basic Metabolic Research) NNF23SA0084103
Abstract
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and efficacy data from NAD
Indexed as
AgingNADNeurodegenerative DiseasesAnimalsHumansNADPNiacinamidePyridinium CompoundsNADNADPNiacinamidenicotinamide-beta-ribosidePyridinium Compounds
Identifiers
PMID
40926126What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.