Evidence map›Paper›PMID 40926182›Full record

ArticleClinical rheumatology2025

Clinical characteristics of IgG4-related lung disease: a single-center based experience.

Dong-Ge Han, Chun-Lin Ying, Tian-Qi Zhao, Qiao-Yun Tong, Wei Liu

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Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Dong-Ge HanThe First College of Clinical Medical Science, Three Gorges University, Yichang, China.
Chun-Lin YingThe First College of Clinical Medical Science, Three Gorges University, Yichang, China.
Tian-Qi ZhaoThe First College of Clinical Medical Science, Three Gorges University, Yichang, China.
Qiao-Yun TongThe First College of Clinical Medical Science, Three Gorges University, Yichang, China. ycxhnk@126.com.
Wei LiuThe First College of Clinical Medical Science, Three Gorges University, Yichang, China. liuwei@ctgu.edu.cn.ORCID http://orcid.org/0000-0001-7118-815X

Funding

Yichang Medical and Health Research Project A24-2-008
6 · The paper itself

Abstract

backgroundIgG4-related lung disease (IgG4-RLD) is a rare autoimmune condition. This study aims to systematically analyze the clinical characteristics of IgG4-RLD to enhance clinicians' awareness and improve patient outcomes.

methodsThis retrospective analysis investigates the clinical data of 20 patients diagnosed with IgG4-RLD at the Yichang Central People's Hospital between January 2019 and April 2025.

resultsThe mean age at diagnosis among the 20 patients with IgG4-RLD was 60.10 ± 10.34 years, with a male-to-female ratio of 3:1. The most frequent clinical manifestations were hemoptysis and abnormalities in pulmonary imaging. Eight patients (40.00%) presented with isolated pulmonary involvement, while 12 patients (60.00%) exhibited extra-pulmonary organ involvement, with lymph node involvement being the most prevalent. The pulmonary imaging characteristics primarily included solid nodular patterns in 10 patients (50.00%) and round ground-glass opacity (GGO) patterns in 9 patients (45.00%). Patients with round GGO patterns exhibited a higher incidence of hemoptysis and predominantly had a history of respiratory conditions (P < 0.05). Patients with solid nodular patterns exhibited significantly higher percentages of eosinophils and lymphocytes, as well as elevated serum IgG levels, compared to those with round GGO patterns (P < 0.05). By contrast, patients with round GGO patterns demonstrated significantly higher percentages of neutrophils and a markedly increased neutrophil-to-lymphocyte ratio (NLR) compared to those with solid nodular patterns (P < 0.05).

conclusionsThe clinical manifestations of IgG4-RLD are complex and heterogeneous. Clinicians need to acquire a thorough understanding of these features in order to develop personalized diagnostic and therapeutic approaches, thereby enhancing patient outcomes. Key Points • The pulmonary imaging characteristics of IgG4-RLD were primarily manifested as solid nodular patterns and round GGO patterns. • Patients with round GGO patterns were more likely to experience hemoptysis, and the majority of these patients presented with a history of respiratory conditions. • Patients with solid nodular patterns demonstrated significantly higher percentages of eosinophils, lymphocytes, and serum IgG levels compared to those with round GGO patterns. • Patients with round GGO patterns demonstrated significantly higher percentages of neutrophils and a markedly increased NLR compared to those with solid nodular patterns.

Indexed as

Immunoglobulin GImmunoglobulin G4-Related DiseaseLung DiseasesAdultAgedFemaleHemoptysisHumansLungMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedImmunoglobulin GClinical characteristicsIgG4-related diseaseIgG4-related lung disease

Identifiers

PMID40926182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.