ArticleLipids in health and disease2025
Body muscle mass versus fat mass: gender-specific associations with NAFLD and liver fibrosis.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aimed to investigate the gender-specific associations of skeletal muscle mass and fat mass with non-alcoholic fatty liver disease (NAFLD) and NAFLD-related liver fibrosis in two population-based studies.
methodsAnalyses were based on data from the MEGA (n = 238) and the MEIA study (n = 594) conducted between 2018 and 2023 in Augsburg, Germany. Bioelectrical impedance analysis was used to evaluate relative skeletal muscle mass (rSM) and SM index (SMI) as well as relative fat mass (rFM) and FM index (FMI); furthermore, the fat-to-muscle ratio was built. The fatty liver index (FLI) was calculated to identify NAFLD. To estimate the degree of liver fibrosis, liver stiffness was assessed in the MEGA study using ultrasound elastography. Multivariable gamma regression models with log-link were used to analyze the respective associations.
resultsAfter adjusting for confounders, FMI and rFM (p < 0.001) as well as SMI (p < 0.001) were significantly positive associated with FLI. The associations were non-linear, and effect modification by gender (p
conclusionsThis population-based study demonstrated gender-specific positive associations between fat mass parameters and FLI, and an inverse association with rSM. Furthermore, for rSM effect modification by age was observed. Neither in men nor in women associations between body composition and liver fibrosis could be identified.
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