SynthesisNutrition journal2025
Dietary inflammatory index and the risk of colorectal adenomas and cancer: a systematic review and dose-response meta-analysis.
Synthesis in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe potential association between dietary inflammatory index (DII) and colorectal cancer (CRC) risk, as well as colorectal adenomas (CRA) risk, has been extensively studied, but the findings remain inconclusive. We conducted this systematic review and dose-response meta-analysis to investigate the relationship between the DII and CRC and CRA.
methodsWe comprehensively searched the PubMed, Embase, Cochrane Library, and Web of Science databases for cohort and case-control studies reporting the relationship between DII and CRA, or between DII and CRC, as of 15 July 2025. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a random-effects model. Dose-response analysis was conducted where possible. Subgroup analyses were conducted to account for possible sources of heterogeneity. Funnel plot, Egger's test, and Begg's test were utilized to assess publication bias.
resultsTwenty-two studies were included, involving 7,612 CRA patients, 25,359 CRC patients, and 896,592 controls. The pooled ORs for CRC and CRA in total population comparing the highest DII to the lowest DII were 1.61 (95% CI, 1.42-1.83) and 1.19 (95% CI, 0.96-1.47), respectively. The pooled ORs for CRC and CRA per unit increase in DII were 1.14 (95% CI, 1.08-1.20) and 1.19 (95% CI, 1.03-1.38), respectively. Stratification by sex revealed a positive association between DII and CRC risk in both males and females. However, this association was stronger in males (Highest DII vs. lowest DII: OR = 1.67, 95% CI [1.39, 2.00]) (Continues DII: OR = 1.16, 95%CI [1.06, 1.26]). Dose-response analysis revealed a nonlinear positive correlation between CRC risk and DII (P
conclusionsOur findings suggest that dietary habits characterized by a high inflammatory index may increase the risk of CRA and CRC. TRIAL REGISTRATION : PROSPERO registration number: CRD42025641934.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.