ArticlePsychological medicine2025
Smaller hippocampal tail volume is associated with plasma CCL11 levels in patients with major depressive disorder.
Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study investigates structural abnormalities in hippocampal subfield volumes and shapes, and their association with plasma CC chemokines in individuals with major depressive disorder (MDD).
methodsA total of 61 patients with MDD and 65 healthy controls (HC) were recruited. All participants underwent high-resolution T1-weighted imaging and provided blood samples for the detection of CC chemokines (CCL2, CCL7, and CCL11). Comparisons of hippocampal subregion volumes, surface shapes, and plasma CC chemokine concentrations were conducted between the MDD and HC groups. Furthermore, partial correlation analysis was performed to assess the relationship between structural abnormalities (hippocampal subfield volume and shape) and plasma CC chemokine levels.
resultsThe MDD group exhibited a significant reduction in the volume of the left hippocampal tail compared to the HC group (
conclusionAbnormally elevated plasma CCL11 in MDD patients may mediate damage to specific hippocampal substructures.
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