Evidence map›Paper›PMID 40926735›Full record

ArticleDiabetes, obesity & metabolism2025

Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation (TSPO availability) in monozygotic twin pairs discordant for BMI-Exercise training reverses increased brain activity.

Jaakko Hentilä, Jouni Tuisku, Ronja Ojala, Lihua Sun, Martin S Lietzén, Heidi Virtanen, Riikka Lautamäki, Kalle Koskensalo, Lauri Nummenmaa, Eliisa Löyttyniemi and 7 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jaakko HentiläTurku PET Centre, University of Turku, Turku, Finland.ORCID 0000-0001-8211-8827
Jouni TuiskuTurku PET Centre, University of Turku, Turku, Finland.
Ronja OjalaTurku PET Centre, University of Turku, Turku, Finland.ORCID 0000-0002-2393-0281
Lihua SunTurku PET Centre, University of Turku, Turku, Finland.
Martin S LietzénTurku PET Centre, University of Turku, Turku, Finland.
Heidi VirtanenTurku PET Centre, University of Turku, Turku, Finland.
Riikka LautamäkiHeart Centre, Turku University Hospital, Turku, Finland.
Kalle KoskensaloDepartment of Medical Physics, Turku University Hospital, Turku, Finland.
Lauri NummenmaaTurku PET Centre, University of Turku, Turku, Finland.
Eliisa LöyttyniemiDepartment of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland.
Semi HelinRadiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland.
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
Leo LahtiDepartment of Computing, University of Turku, Turku, Finland.
Tarja MalmA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Juha O RinneTurku PET Centre, University of Turku, Turku, Finland.
Jarna C HannukainenTurku PET Centre, University of Turku, Turku, Finland.

Funding

Emil Aaltonen FoundationHospital District of Southwest FinlandKyllikki and Uolevi Lehikoinen foundationMaija and Matti Vaskio FoundationMaud Kuistila memorial foundationResearch Council of Finland 317332Research Council of Finland 352792The Diabetes research foundation of FinlandThe Finnish cultural foundationthe Turku Finnish University SocietyTurku University FoundationUniversity of Turku Doctoral Programmes in Clinical ResearchVarsinais-Suomi Regional Fund
6 · The paper itself

Abstract

aimsObesity is associated with increased insulin-stimulated brain glucose uptake (BGU) which is opposite to decreased GU observed in peripheral tissues. Increased BGU was shown to be reversed by weight loss and exercise training, but the mechanisms remain unknown. We investigated whether neuroinflammation (TSPO availability) and brain activity drive the obesity-associated increase in BGU and whether this increase is reversed by exercise training. MATERIALS AND

methodsTwelve monozygotic twin pairs mean age 40.4 (SD) years discordant for BMI (leaner mean 29.1 (SD) 6.3, heavier 36.7 (SD) 7.0 kg·m

resultsExercise training had no effect on insulin-stimulated BGU, brain neuroinflammation (TSPO availability), or BMI. Exercise improved VO

conclusionsExercise training had no effect on insulin-stimulated BGU or neuroinflammation (TSPO availability) but it reversed increased resting state brain activity in heavier co-twins. At baseline, obesity was associated with increased insulin-stimulated BGU and resting state brain activity, independent of genetics.

Indexed as

BrainExerciseGlucoseNeuroinflammatory DiseasesObesityAdultBody Mass IndexExercise TherapyFemaleGlucose Clamp TechniqueHumansInsulinInsulin ResistanceMagnetic Resonance ImagingMaleMiddle AgedGlucoseInsulinbrain inflammationcognitive functioninsulin resistancepositron emission tomographyresting state functional magnetic resonance imaging

Identifiers

PMID40926735
PMCPMC12587225

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.