ReviewAlpha psychiatry2025
Molecular Mechanism of Antidepressant Effects of Active Ingredients in Traditional Chinese Medicine: The Role of Autophagy.
Review in Alpha psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In clinical practice, selective serotonin reuptake inhibitors (SSRIs), a kind of Western medicine, are the primary treatment for depression, a complex mental illness. However, these treatments are associated with significant adverse reactions. With their many benefits and distinctive features, such as all-encompassing intervention and general control through several targets, processes, and pathways, the active components in traditional Chinese medicine (TCM) hold great promise for the treatment of depression. Autophagy plays a crucial role in the pathophysiology of depression, and its regulation has emerged as a potentially crucial management tactic. However, comprehensive evaluations of the link between depression and mitochondrial autophagy, as well as the therapeutic potential of TCM's active components, remain limited. This review examined recent literature on autophagy and its role in depression, along with studies on the effects of TCM active ingredients. Furthermore, it highlighted the limitations of current research to offer insights to guide future fundamental studies and clinical treatments for depression.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.