Evidence map›Paper›PMID 40926896›Full record

ReviewFrontiers in cardiovascular medicine2025

Protein kinase C and endothelial dysfunction in select vascular diseases.

Shawn Kant, Jun Feng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shawn KantCardiothoracic Surgery Research Laboratory, Department of Medicine, Rhode Island Hospital, Brown University Health, Providence, RI, United States.
Jun FengDepartment of Surgery, Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein kinases have crucial roles in intracellular signal transduction pathways that affect a wide range of biochemical processes, including apoptosis, metabolism, proliferation, and protein synthesis. Vascular endothelial cells are important regulators of vasomotor tone, tissue/organ perfusion, and inflammation. Since its discovery in the late 1970s, a growing body of literature implicates protein kinase C (PKC) in pathways involving angiogenesis, endothelial permeability, microvascular tone, and endothelial activation. Hence the objective of this review, to characterize the role of PKC in vascular endothelial cells. After discussing the basic principles of PKC structure and function, the focus shifts to abnormal PKC activity driving endothelial dysfunction in three major pathologies whose hallmark is significant vascular disease: diabetes mellitus, hypoxia/ischemia-reperfusion injury, and hypertension. Themes addressed include endothelial cell cycle derangement, endothelial oxidative stress, endothelial activation/inflammation, and impaired endothelial barrier integrity. Achieving a comprehensive understanding of endothelial cell-PKC pathophysiology may lead to development of new therapeutic targets for mitigating morbidity and mortality in these disease states.

Indexed as

diabetesendothelial cellhypertensionischemia-reperfusionPKCvascular function

Identifiers

PMID40926896
PMCPMC12414950

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.