ArticlePatterns (New York, N.Y.)2025
The tree-based pipeline optimization tool: Tackling biomedical research problems with genetic programming and automated machine learning.
Article in Patterns (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Agentic AI and the rise of in silico team science in biomedical research.Nature biotechnology · 2026Review
- SensorAI: A Machine Learning Framework for Sensor Data.Sensors (Basel, Switzerland) · 2025Article
- Quantum-Inspired gravitationally guided particle swarm optimization for feature selection and classification.Scientific reports · 2025Article
- Glioma Grading by Integrating Radiomic Features from Peritumoral Edema in Fused MRI Images and Automated Machine Learning.Journal of imaging · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The tree-based pipeline optimization tool (TPOT) is one of the earliest automated machine learning (ML) frameworks developed for optimizing ML pipelines, with an emphasis on addressing the complexities of biomedical research. TPOT uses genetic programming to explore a diverse space of pipeline structures and hyperparameter configurations in search of optimal pipelines. Here, we provide a comparative overview of the conceptual similarities and implementation differences between the previous and latest versions of TPOT, focusing on two key aspects: (1) the representation of ML pipelines and (2) the underlying algorithm driving pipeline optimization. We also highlight TPOT's application across various medical and healthcare domains, including disease diagnosis, adverse outcome forecasting, and genetic analysis. Additionally, we propose future directions for enhancing TPOT by integrating contemporary ML techniques and recent advancements in evolutionary computation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.