ArticleJGH open : an open access journal of gastroenterology and hepatology2025
Ammonia-to-Urea Ratio: A Noninvasive First-Line Tool for Detecting Clinically Significant Portal Hypertension.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Reconsidering the urea-to-creatinine ratio as a signal of muscle catabolism in patients with cirrhosis.Critical care (London, England) · 2025Article
- Ammonia-to-Urea Ratio: A Noninvasive First-Line Tool for Detecting Clinically Significant Portal Hypertension.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Cirrhosis progresses from compensated to decompensated phases, often marked by portal hypertension and complications like ascites, variceal hemorrhage, and hepatic encephalopathy. The ammonia-to-urea (A-to-U) ratio, reflecting urea cycle efficiency, may offer superior diagnostic performance compared to plasma ammonia levels alone. This study compared the diagnostic accuracy of the A-to-U ratio and plasma ammonia levels for identifying portal hypertension. Methods: We conducted a derivation (2019-2020) and validation (2020-2022) study in patients with chronic liver disease. In the derivation study, outcomes included imaging findings of portal hypertension and clinically significant portal hypertension (CSPH) per BAVENO VII criteria. Validation outcomes encompassed CSPH, gastroesophageal varices, and portal hypertensive gastropathy. Results: In the derivation study ( Discussion: Our study suggests that an A-to-U ratio > 1.53 mg/g may serve as a useful noninvasive tool for identifying CSPH, gastroesophageal varices, and portal hypertensive gastropathy in patients with chronic liver disease.
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Registered trials
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