Evidence map›Paper›PMID 40927570›Full record

ArticleFrontiers in nutrition2025

The

Francesca Coperchini, Fabrizio De Luca, Alessia Greco, Laura Croce, Elena Franchi, Marsida Teliti, Patrizia Pignatti, Flavia Magri, Maria Grazia Bottone, Mario Rotondi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Heme oxygenase-1 in thyroid cancer: a context-dependent regulator.Journal of endocrinological investigation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesca CoperchiniDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Fabrizio De LucaDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Alessia GrecoDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Laura CroceDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Elena FranchiDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Marsida TelitiDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Patrizia PignattiAllergy and Immunology Unit, ICS Maugeri IRCCS, Pavia, Italy.
Flavia MagriDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Maria Grazia BottoneDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Mario RotondiDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Voghera pepper (VP) extracts were demonstrated to have anti-oxidant ability in several cell types. Purpose: This study aimed to assess whether VP-extracts could lower oxidative stress and modulate thyroid cancer (TC) cells behavior Methods: Extracts were analyzed using the LC-DAD-MS system. Thyroid cell lines, both normal (NHT) and cancerous (TPC-1 and 8505C) were treated with increasing concentrations of Yellow (YVP) and Green (GVP) VP-extracts over time. Viability and proliferation were assessed in all cell types. Changes in Reactive-oxygen-species (ROS) production by TPC-1 and 8505C were assessed by flow-cytometry. The mRNA expression of anti-oxidant mediators ( Results: Treatment with GVP or YVP reduced the viability of TPC-1 and 8505C but not those of NHT, without effects on cells proliferation. GVP and YVP reduced basal and H Conclusion: This is the first demonstration of the potential beneficial effects of VP extracts in TC in terms of reduction of oxidative stress, increase of antioxidant markers, and modulation of markers of metastasis and de-differentiation in TC cells.

Indexed as

anti-oxidant genesoxidative stressphytochemicalROSthyroid cancerVoghera pepper

Identifiers

PMID40927570
PMCPMC12414954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.