Evidence map›Paper›PMID 40927631›Full record

ArticleMaterials today. Bio2025

US-triggered on-demand NO-releasing biomimetic nanoparticle to Remodel endothelial microenvironment for enhancing atherosclerosis-specific gas therapy.

Lingling Xu, Daifang Zhang, Li Song, Yifei Wu, Longqi Jiang, Zhenyu Liu, Xin Qian, Jun Zhou, Yong Liu, Ya Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lingling XuDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430022, China.
Daifang ZhangDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China.
Li SongDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 646000, Luzhou, China.
Yifei WuDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China.
Longqi JiangDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China.
Zhenyu LiuDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China.
Xin QianDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China.
Jun ZhouDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, 646000, Luzhou, China.
Yong LiuDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China.
Ya WuDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS) is a chronic inflammatory disease driven by endothelial dysfunction, vascular smooth muscle cell proliferation, and insufficient resolution of inflammation. Nitric oxide (NO) plays a crucial role in vascular homeostasis by promoting endothelial cell proliferation, maintaining endothelial integrity, suppressing smooth muscle cell hyperplasia, and exerting potent anti-inflammatory effects. However, clinical application of NO is hindered by its short half-life, lack of targeting, and uncontrolled release. Here, we developed the biomimetic nanoparticles (B-NPs@MM) for targeted and controllable NO delivery by encapsulating the ultrasound (US)-responsive NO donor BNN6 into poly(lactic-co-glycolic acid) (PLGA) nanospheres followed by coating with macrophage-derived membranes. These biomimetic particles mimic natural macrophages to actively target inflamed atherosclerotic plaques and evade immune clearance. Upon localized US exposure, the system triggers rapid and on-demand NO release at the lesion site with spatiotemporal precision.

Indexed as

AtherosclerosisBiomimetic nanoparticlesNitric oxideUltrasound-responsive

Identifiers

PMID40927631
PMCPMC12415076

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.