Evidence map›Paper›PMID 40927646›Full record

Trial reportCritical care explorations2025

Vitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of the Lessening Organ Dysfunction With Vitamin C Randomized Trial.

Mattia M Müller, Ruxandra Pinto, François Lamontagne, Neill K J Adhikari, Lorenzo Del Sorbo, Lessening Organ Dysfunction With Vitamin C (LOVIT) Investigators

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03680274 (Lessening Organ Dysfunction With VITamin C), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03680274 phase3completednot on this map

Lessening Organ Dysfunction With VITamin C (LOVIT)

TypeinterventionalSponsorUniversité de SherbrookeRan2018 to 2022Enrolled872ConditionsSepsis, Vitamin C, Intensive Care Unit, COVID-19ArmsVitamin C, Control
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mattia M MüllerInstitute of Intensive Care Medicine, University Hospital Zurich, Zurich, ZH, Switzerland.ORCID https://orcid.org/0000-0003-2615-2259
Ruxandra PintoDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
François LamontagneDepartment of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada.
Neill K J AdhikariDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Lorenzo Del SorboInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Lessening Organ Dysfunction With Vitamin C (LOVIT) Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveVitamin C has been linked to alterations in platelet count and aggregation behavior. Given recent findings suggesting an association between vitamin C and adverse outcomes in patients with septic shock, we aimed to investigate whether vitamin C influences mortality in septic patients through its impact on platelets.

designPost hoc analysis of the Lessening Organ Dysfunction With Vitamin C (LOVIT) randomized trial (clinicaltrials.gov NCT03680274).

settingMulticenter international study. PATIENTS: Patients were included with an ICU stay of more than 24 hours, confirmed or suspected infection, vasopressor requirement, and availability of platelet count data.

interventionVitamin C (50 mg/kg body weight) every 6 hours for 4 days, or placebo. MEASUREMENTS AND MAIN

resultsOf the 863 patients enrolled in the LOVIT trial, 859 had available platelet count data at any time. Although the longitudinal trajectory of platelet count was significantly associated with 28-day mortality (hazard ratio 0.97 per 10 × 10

conclusionsThese results do not support the hypothesis that vitamin C administration increases mortality risk by affecting platelet count.

Indexed as

Ascorbic AcidMultiple Organ FailureSepsisVitaminsAgedFemaleHumansIntensive Care UnitsMaleMiddle AgedPlatelet CountAscorbic AcidVitaminsblood coagulation disorderblood plateletsmortalityorgan failuresepsisshock

Identifiers

PMID40927646
PMCPMC12417011

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.